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TranscriptomicsEffects of Combined Persistant Organic Pollutants on Global Gene Expression in Human HepaRG Cells
The exposure to and contamination by Persistent Organic Pollutants (POPs), which include pesticides used worldwide and polyaromatic hydrocarbons, is detrimental to human health and diverse ecosystems. Although most mechanistic studies have focused on single compounds, living organisms are exposed to...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-46874 | biostudies-arrayexpress
TranscriptomicsScreening of the Paramecium tetraurelia megabase chromosome for autogamy-specific genes
Total RNA was extracted at different stages (TV, T0, T11 and T20) during autogamy of strain d4-2. Genes specifically induced during autogamy were identified following analysis of microarray hybridization data 3 technical replicates of the time course were hybridized Subset one and three were labell...
ORGANISM(S): Paramecium tetraurelia 
2010-05-06 | E-GEOD-12988 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver exposed to 24h cytokine starvation vs. treatment with TNF alpha
Pathogenesis of atherosclerosis results from the interactions between disrupted lipid homeostasis and immune response but the molecular bridges between the major players are still a matter of controversy. We investigated the systemic effect of inflammatory cytokine tumor necrosis factor alpha (TNF-Î...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6317 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with phenobarbital and fed a high cholesterol diet an
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were anayzed using Affymetrix GeneChip MOE430A. Experiment Overall Design: One group of mic...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6721 | biostudies-arrayexpress
Transcriptomicsdyrk1a
Transcription profiling of transgenic down syndrome mouse model to show the role of DYRK1A gene. The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse m...
ORGANISM(S): Mus musculus 
2010-05-05 | E-GEOD-14072 | biostudies-arrayexpress
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