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UnknownNovel Thioxothiazolo[3,4-a]quinazolin-5(4H)-one Derivatives as BKCa Channel Activators for Urinary Incontinence.
Overactive bladder (OAB) is a syndrome causing a sudden and unstoppable need to urinate with significant global prevalence. Several drugs are used to treat OAB; however, they have various side effects. Therefore, new treatment options for OAB are required. A series of novel 5-oxo-N-phenyl-1-t...
S-EPMC9290006 | biostudies-literature
UnknownAlteration in cerebrospinal fluid flow based on the neurological prognosis of out-of-hospital cardiac arrest patients.
We evaluated alterations in cerebrospinal fluid (CSF) flow based on the neurological prognosis of out-of-hospital cardiac arrest (OHCA) patients. This prospective observational study was conducted from May 2023 to June 2024. Stroke distance was measured using magnetic resonance imaging flowmetry imm...
S-EPMC11489757 | biostudies-literature
UnknownFrom grass to battery anode: agricultural biomass hemp-derived carbon for lithium storage.
Biomass-derived carbon, as a low-cost material source, is an attractive choice to prepare carbon materials, thus providing an alternative to by-product and waste management. Herein, we report the preparation of carbon from hemp stem as a biomass precursor through a simple, low-cost, and environment-...
S-EPMC9086231 | biostudies-literature
UnknownAssociation of ultra-early diffusion-weighted magnetic resonance imaging with neurological outcomes after out-of-hospital cardiac arrest.

Background

This study aimed to investigate the association between ultra-early (within 6 h after return of spontaneous circulation [ROSC]) brain diffusion-weighted magnetic resonance imaging (DW-MRI) and neurological outcomes in comatose survivors after out-of-hospital cardiac arrest.

Met...

S-EPMC9837995 | biostudies-literature
UnknownNeurologic Dysfunction Assessment in Parkinson Disease Based on Fundus Photographs Using Deep Learning.

Importance

Until now, other than complex neurologic tests, there have been no readily accessible and reliable indicators of neurologic dysfunction among patients with Parkinson disease (PD). This study was conducted to determine the role of fundus photography as a noninvasive and readily ava...
S-EPMC9912166 | biostudies-literature
UnknownDistribution and elimination kinetics of midazolam and metabolites after post-resuscitation care: a prospective observational study.
Administration of sedatives for post-resuscitation care can complicate the determination of the optimal timing to avoid inappropriate, pessimistic prognostications. This prospective study aimed to investigate the distribution and elimination kinetics of midazolam (MDZ) and its metabolites, and their...
S-EPMC10894853 | biostudies-literature
UnknownEfficacy of Nitric Oxide-Releasing Nanofibers in Reducing Renal Ischemia-Reperfusion Injury in a Rat Model.
BACKGROUND This study aimed to analyze the preventive effect of nitric oxide (NO)-releasing nanofibers against ischemia-reperfusion injury (IRI) and to determine the mechanism of action as a novel NO delivery system in a rat model. MATERIAL AND METHODS Eight-week-old male Sprague-Dawley rats, weighi...
S-EPMC8790936 | biostudies-literature
UnknownCombination strategy for prognostication in patients undergoing post-resuscitation care after cardiac arrest.
This study investigated the prognostic performance of combination strategies using a multimodal approach in patients treated after cardiac arrest. Prospectively collected registry data were used for this retrospective analysis. Poor outcome was defined as a cerebral performance category of 3-5 at 6 ...
S-EPMC10711008 | biostudies-literature
UnknownSex differences in in-hospital management in patients with sepsis and septic shock: a prospective multicenter observational study.
Sex differences in the in-hospital management of sepsis exist. Previous studies either included patients with sepsis that was defined using previous definitions of sepsis or evaluated the 3-h bundle therapy. Therefore, this study sought to assess sex differences in 1-h bundle therapy and in-hospital...
S-EPMC10901798 | biostudies-literature
UnknownSpherical Sulfur-Infiltrated Carbon Cathode with a Tunable Poly(3,4-ethylenedioxythiophene) Layer for Lithium-Sulfur Batteries.
Li-S batteries have received significant attention owing to their high energy density, nontoxicity, low cost, and eco-friendliness. However, the dissolution of lithium polysulfide during the charge/discharge process and its extremely low electron conductivity hinder practical applications of Li-S ba...
S-EPMC10324086 | biostudies-literature
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