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During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD073702 | Pride
During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD065726 | Pride
During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD065746 | Pride
During obesity and type 2 diabetes, pancreatic β-cells face chronic environmental stress, while islet-resident macrophages (iMACs) undergo metabolic reprogramming that exacerbates β-cell dysfunction. Stress-induced cleavage of tRNAs generates tRNA-derived fragments (tRFs), whose role in this context...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-12 | PXD065736 | Pride
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