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ProteomicsAIM2 in regulatory T (Treg) cells restrains autoimmune diseases
The inflammasome initiates innate defense and inflammatory response by activating caspase-1 and pyroptotic cell death in myeloid cells1,2. It is comprised of an innate immune receptor/effector, pro-caspase-1 and a common adaptor molecule, ASC (apoptotic speck-containing protein with a CARD). Consis...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-27 | PXD018638 | Pride
Autoimmunity Aim2 (absent in melanoma 2) Akt-mtor signaling 
GenomicsAbsent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells
Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells
PRJNA764738 | ENA
TranscriptomicsAIM2-responsive genes in colorectal tumor cells
Absent in Melanoma 2 (AIM2) is a member of the HIN-200 family of hematopoietic, IFN-inducible nuclear proteins associated with infection defense and tumor pathology. Recently, AIM2 was found to act as a DNA sensor in innate immunity. In addition, a high frequency of AIM2-alterations was observed in ...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-24155 | biostudies-arrayexpress
TranscriptomicsAbsent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells
Absent in melanoma 2 (AIM2) is a cytosolic dsDNA sensor that has been broadly studied for its role in inflammasome assembly. However, little is known about the function of AIM2 in adaptive immune cells. The purpose of this study was to investigate whether AIM2 has a cell-intrinsic role in CD4+ T cel...
ORGANISM(S): Mus musculus 
2022-05-27 | GSE184479 | GEO
UnknownAbsent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells.
Not available
S-EPMC8876789 | biostudies-literature
GenomicsDeletion of absent in melanoma (AIM) 2 gene drives bone marrow adipogenesis
Deletion of absent in melanoma (AIM) 2 gene drives bone marrow adipogenesis
PRJNA1139222 | ENA
UnknownStructure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly.
Not available
S-EPMC3650362 | biostudies-literature
UnknownSingle-Nucleotide Variants in the AIM2 - Absent in Melanoma 2 Gene (rs1103577) Associated With Protection for Tuberculosis.
Not available
S-EPMC8047195 | biostudies-literature
GenomicsAbsent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy
Absent in melanoma 2: a potent suppressor of retinal pigment epithelial-mesenchymal transition and experimental proliferative vitreoretinopathy
PRJNA1190897 | ENA
TranscriptomicsDeletion of absent in melanoma (AIM) 2 gene drives bone marrow adipogenesis
Absent in Melanoma (AIM) 2 is a gene that is induced by interferon and acts as a cytosolic sensor for double-stranded (ds) DNA. It forms the AIM2 inflammasome, leading to the production of interleukin (IL)-1β and IL-18. Our previous study demonstrated that mice lacking AIM2 exhibit spontaneous obesi...
ORGANISM(S): Mus musculus 
2025-03-12 | GSE272915 | GEO
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