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MetabolomicsCirculating Metabolites in Progression to Islet Autoimmunity and Type 1 Diabetes

AIMS/HYPOTHESIS: Metabolic dysregulation may precede the onset of type 1 diabetes. However, these metabolic disturbances and their specific role in disease initiation remain poorly understood. In this study, we examined whether children who progress to type 1 diabetes have a cir...

2022-01-19 | MTBLS802 | MetaboLights
MetabolomicsLignans redress autoimmunity and achieve curative effects on myasthenia gravis by ameliorating the gut microbiome

Myasthenia gravis (MG) is a serious inflammatory autoimmune disease characterized by continuous production of autoantibodies against targets in the neuromuscular junctions, resulting in muscle weakness. Autoimmunity has long been presumed to be irreversible. The current therapeutic regimens may a...

2025-10-24 | MTBLS12842 | MetaboLights
MetabolomicsDynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes: Type 1 Diabetes Prediction and Prevention Study (DIPP)
Type 1 diabetes (T1D) is one of the most prevalent autoimmune diseases among children in Western countries. Earlier metabolomics studies suggest that T1D is preceded by dysregulation of lipid metabolism. Here we used a lipidomics approach to analyze molecular lipids in a prospective series of 428 pl...
2018-07-16 | MTBLS620 | MetaboLights
MetabolomicsLoss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells

Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we fo...

2026-02-06 | MTBLS13473 | MetaboLights
MetabolomicsDynamics of bile acid metabolism between the host and gut microbiome in progression to islet autoimmunity (Feces)
Not available
ORGANISM(S): Homo sapiens 
ST001992 | MetabolomicsWorkbench
MetabolomicsDynamics of bile acid metabolism between the host and gut microbiome in progression to islet autoimmunity (Blood)
Not available
ORGANISM(S): Homo sapiens 
ST001991 | MetabolomicsWorkbench
TranscriptomicsNetwork analysis identifies proinflammatory plasma cell polarization for secretion of ISG15 in human autoimmunity
Plasma cells (PCs) as effectors of humoral immunity produce immunoglobulins to match pathogenic insult. However, emerging data suggests more diverse roles for PCs as regulators of immune and inflammatory responses via secretion of factors other than immunoglobulins. The extent to which such response...
ORGANISM(S): Homo sapiens 
2016-07-22 | E-GEOD-75007 | biostudies-arrayexpress
TranscriptomicsSex-specific control of CNS autoimmunity by p38 MAPK signaling in myeloid cells
Objective: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), characterized by a global increasing incidence driven by relapsing-remitting disease in females. p38 MAP kinase (MAPK) has been described as a key regulator of inflammatory respons...
ORGANISM(S): Mus musculus 
2013-10-29 | E-GEOD-51707 | biostudies-arrayexpress
ProteomicsRelative complement deficiency predicts development of islet autoimmunity and type 1 diabetes
Complement proteins were measured using selected reaction monitoring (SRM)-based targeted proteomics.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-12-06 | MSV000090848 | MassIVE
ProteomicsStool metaproteomics of children with islet autoimmunity
The gastrointestinal ecosystem is a highly complex environment with a profound influence on human health. Inflammation in the gut, linked to an altered gut microbiome has been associated with the development of multiple human conditions including type 1 diabetes (T1D). Viruses infecting the gastroin...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD032997 | Pride
T1d metaproteome 
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