Airway epithelial cells

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Unknown (3437)
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Organisms

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Mycobacterium avium 104 (1)
Saccharomyces cerevisiae x Saccharomyces paradoxus (1)
Drosophila willistoni (1)
Synechococcus sp. WH 7803 (1)

Organisms

Homo sapiens (587)
Mus musculus (187)
Drosophila melanogaster (7)
Sus scrofa (5)
Pseudomonas aeruginosa (3)
Rattus norvegicus (3)
Python regius (2)
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upper respiratory tract metagenome (1)
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human respiratory syncytial virus (1)
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Mus (1)
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Repository

biostudies-arrayexpress (979)
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geo (731)
pride (73)
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dbGaP (1)
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MetabolomicsWorkbench (1)

Tissue

Epithelial cell (41)
Cell culture (30)
Lung (17)
Bronchial epithelial cell (5)
Epithelial cell of lung (2)
Primary cell (2)
Respiratory epithelial cell (2)
Cultured cells (1)
Bronchial epithelial cell line (1)
Bronchial smooth muscle cell (1)
Cell suspension culture (1)
Colon (1)
Fibroblast (1)
Group 2 innate lymphoid cell (1)
Kidney (1)
Lung cell line (1)
Nasal cavity epithelium (1)
Nasal epithelium cell line (1)
Nasal mucosa (1)
Spleen (1)
T cell (1)

Disease

Normal (14)
Cystic fibrosis (7)
Asthma (4)
Respiratory syncytial virus infectious disease (4)
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COVID-19 (2)
FRD1234 (1)
Pseudomonas aeruginosa rsmA mutant infected (1)
Perilobar nephrogenic rest (1)
Post-stasis (1)
Xenografts with H1299 cell line (1)
Non-CF (1)
Chronic myelogenous leukemia (1)
Carcinoma (1)
Adenocarcinoma (1)
Ovarian cancer (1)
Allergic asthma (1)
Avian influenza (1)
Chronic obstructive pulmonary disease (1)
Colon cancer (1)
Disease free (1)
Lung cancer (1)
Nipah virus encephalitis (1)
Severe acute respiratory syndrome (1)

Technology Type

Mass Spectrometry (74)
Shotgun proteomics (45)
Bottom-up proteomics (13)
Data-dependent acquisition (7)
Data-independent acquisition (4)
SWATH MS (4)
Affinity purification coupled with mass spectrometry proteomics (3)
Top-down proteomics (3)
Mass spectrometry (2)
Mass spectrometry assay (1)
ESI (1)
DiaPASEF (1)
SRM/MRM (1)

Instrument Platform

Illumina NovaSeq 6000 (69)
NextSeq 500 (35)
Illumina HiSeq 4000 (25)
Illumina HiSeq 2500 (22)
Illumina HiSeq 2000 (13)
Illumina MiSeq (9)
NextSeq 2000 (8)
Affymetrix GeneChip Scanner 3000 7G (5)
N/A (5)
Illumina Genome Analyzer IIx (4)
Illumina NovaSeq X (4)
10x Genomics Chromium Controller (4)
NextSeq 550 (4)
Illumina HiSeq 1500 (3)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
Single cells were captured using the 10x Genomics Chromium Controller. (2)
Element AVITI (2)
Axon Instruments GenePix 4000B scanner (2)
Agilent G2505B scanner (2)
Axon GenePix 4000B scanning hardware (2)
Illumina HiSeq 3000 (2)
Hamamatsu Nanozoomer S60 (1)
Bravo automated liquid handling robot station (Agilent) (1)
Chromium Next GEM Single Cell Multiome Reagent Bundle (1)
10X Genomics reagents (1)
Chromium Next GEM Chip G (1)
10X v3 (1)
10x Chromium controller (1)
RNA Qubit (Invitrogen Q32852) (1)
Zymo Quick-RNA Microprep Kit (Zymo Research R1051) (1)

Publication Date

2014 (131)
2026 (116)
2025 (114)
2012 (112)
2011 (112)
2022 (107)
2015 (104)
2020 (102)
2021 (99)
2010 (98)
2024 (97)
2023 (95)
2013 (95)
2018 (78)
2016 (70)
2008 (69)
2019 (56)
2009 (56)
2017 (45)
2007 (37)
2006 (19)
2005 (8)
2004 (8)
2003 (1)

UNIPROT ID/AC

10090.ENSMUSP00000032399 (2)
10090.ENSMUSP00000097919 (2)
1433B_MOUSE (2)
1433E_MOUSE (2)
1433F_MOUSE (2)
1433G_MOUSE (2)
1433S_MOUSE (2)
1433T_MOUSE (2)
1433Z_MOUSE (2)
2A5A_MOUSE (2)
2A5E_MOUSE (2)
2A5G_MOUSE (2)
2AAA_MOUSE (2)
2AAB_MOUSE (2)
2ABA_MOUSE (2)
3BP1_MOUSE (2)
3HIDH_MOUSE (2)
4EBP1_MOUSE (2)
4F2_MOUSE (2)
5NT3B_MOUSE (2)
5NTC_MOUSE (2)
5NTD_MOUSE (2)
6PGD_MOUSE (2)
6PGL_MOUSE (2)
A0A0G2JDV3_MOUSE (2)
A0A0R4J159_MOUSE (2)
A0A140LIF8_MOUSE (2)
A0A1W2P6N8_MOUSE (2)
A0A286YCX6_MOUSE (2)
A0A2I3BQ48_MOUSE (2)

CHEBI ID

CHEBI:16709 (2)
CHEBI:27470 (2)
CHEBI:16946 (2)
CHEBI:15971 (2)
CHEBI:18050 (2)
CHEBI:16283 (2)
CHEBI:17203 (2)
CHEBI:18019 (2)
CHEBI:16015 (2)
CHEBI:16467 (2)
CHEBI:16977 (2)
CHEBI:17154 (2)
CHEBI:16414 (2)
CHEBI:17191 (2)
CHEBI:15603 (2)
CHEBI:16643 (2)
CHEBI:17895 (2)
CHEBI:17295 (2)
CHEBI:16261 (1)
CHEBI:17717 (1)
CHEBI:88766 (1)
CHEBI:168563 (1)
CHEBI:7872 (1)
CHEBI:16374 (1)
CHEBI:17769 (1)
CHEBI:165853 (1)
CHEBI:63906 (1)
CHEBI:18051 (1)
CHEBI:36503 (1)
CHEBI:169293 (1)

Metabolite Name

L-Cystine (2)
L-Alanine (2)
Pyridoxine (2)
L-Kynurenine (2)
L-Histidine (2)
Niacinamide (2)
L-Proline (2)
L-Arginine (2)
L-Lysine (2)
L-Glutamic acid (2)
L-Glutamine (2)
L-Valine (2)
L-Isoleucine (2)
L-Leucine (2)
L-Methionine (2)
L-Tyrosine (2)
L-Phenylalanine (2)
Chitosan (1)
Sulfoacetaldehyde (1)
Dimethylsulfide (1)
Dolichol-20 (1)
Vitamin K2 (1)
Oxytocin (1)
Adenosine phosphosulfate (1)
Paromomycin (1)
Cis-zeatin (1)
QH2 (1)
All-trans-retinoic acid (1)
Retinal (1)
L(-)-Nicotine (1)

IsPrivate

False (2)

First Public Date

2014 (129)
2024 (111)
2025 (105)
2026 (101)
2022 (83)
2020 (81)
2021 (80)
2023 (72)
2018 (41)
2017 (38)
2019 (34)
2016 (18)
2015 (16)
2013 (10)

Classification

bacteria (4)
viruses (2)
fungi (1)

Modelling Approach

Ordinary differential equation model (2)

Study type

Transcription profiling by array (536)
RNA-seq of coding RNA (111)
ChIP-seq (67)
RNA-seq of coding RNA from single cells (62)
Other (20)
Methylation profiling by array (19)
RNA-seq of non coding RNA (17)
Methylation profiling by high throughput sequencing (16)
ChIP-chip by array (14)
Comparative genomic hybridization by array (14)
ChIP-chip by tiling array (12)
RNA-seq of total RNA (9)
Unknown experiment type (8)
ATAC-seq (7)
Cell line - High-throughput sequencing (6)
Transcription profiling by RT-PCR (6)
Proteomic profiling by array (6)
Genotyping by array (4)
Cell line - One-color microarray (3)
Animal - High-throughput sequencing (3)
Single nucleus RNA sequencing (3)
MicroRNA profiling by array (3)
DNA-seq (3)
Transcription profiling by SAGE (2)
Cell line - Single-cell sequencing (2)
MNase-seq (2)
RNA-seq of non coding RNA from single cells (2)
Human - Single-cell sequencing (2)
Plant - One-color microarray (2)
Human - One-color microarray (2)

Release Date

2022 (429)
2021 (365)
2023 (351)
2020 (348)
2025 (265)
2024 (250)
2018 (239)
2015 (228)
2016 (223)
2014 (222)
2019 (209)
2011 (191)
2013 (182)
2017 (180)
2012 (178)
2010 (143)
2009 (108)
2008 (101)
2026 (58)
2007 (58)
2006 (36)
2005 (17)
2004 (15)
2003 (4)
2001 (4)
1999 (4)
2000 (2)
1998 (2)
1997 (2)
2002 (1)

Lab affiliation

University of Texas Medical Branch (8)
Chair in Infection and Global Health, Department of Infection Biology, Institute of Infection and Global Health, University of Liverpool, (2)
Karolinska Institutet (2)
School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney (2)
2Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Madison, WI 53705, USA (1)
Analytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego 30, 16163, Genova, Italy (1)
Associate Professor, Department of Biochemistry & Molecular Biology, UTMB Mass Spectrometry Director, University of Texas Medical Branch – Galveston, Texas, USA (1)
Baxter Laboratory for Stem Cell Biology Department of Microbiology & Immunology Stanford University School of Medicine 269 Campus Drive Stanford, CA 94305-5175, USA (1)
Bowling Green State University (1)
Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK (1)
Cambridge Institute of Therapeutic Immunology and Infectious Disease Jeffrey Cheah Biomedical Centre Cambridge Biomedical Campus Puddicombe Way Cambridge CB2 OAW (1)
Competence Center Functional Genomics, Junior Research Group Pathoproteomics, University of Greifswald, 17489 Greifswald, Germany (1)
Core Unit Proteomics, Berlin Institute of Health at Charite- Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine (MDC), 13125 Berlin, Germany (1)
Department of Biochemistry and Molecular Biology, Oklahoma Center for Respiratory and Infectious Diseases, Oklahoma State University, Stillwater, Oklahoma, USA (1)
Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, United States of America (1)
Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85724 Asthma and Airway Disease Research Center, Tucson, AZ 85724 (1)
Department of Chemistry, Vanderbilt University (1)
Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, 792 Elizabeth St, Melbourne, 3000, Victoria, Australia. (1)
Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, Oklahoma, United States (1)
Department of Microgravity and Translational Regenerative Medicine, Otto-von-Guericke University Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany (1)
Department of Oncology and Pathology, Karolinska Institute and Science for Life Laboratory (1)
Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China (1)
Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite ‐ Universitatsmedizin, Germany; German Center for Lung Research (DZL), Associated Partner Site, Germany; Berlin Institute of Health (BIH) at Charité - Universitätsmedizin Berlin, Germa (1)
Department of Pharmacology School of Medicine University of Texas Medical Branch at Galveston (1)
Department of Respiratory, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Department of Respiratory, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Respiratory Diseases. (1)
Department: Department of Microbiology and Immunology Lab: Host and Pathogen Interactivity Lab Institute: National University of Singapore Country: Singapore (1)
Division of Immunobiology, Cincinnati Children’s Hospital, Cincinnati, OH Department of Pediatrics, University of Cincinnati, Cincinnati OH Correspondence: (1)
Dufour Lab, University of Calgary, department of Physiology and Pharmacology, Biochemistry and Molecular Biology (1)
Duke University (1)
Friedrich-Loeffler-Institut (1)

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Timecourse on primary human highly differentiated airway epithelial cells infected with HRV-C15

Not available

ORGANISM(S): Homo sapiens

ST001774 | MetabolomicsWorkbench

Multi-omic Landscape of Airway Microbe-Host Interactions in Chronic Obstructive Pulmonary Disease

The mechanistic role of the airway microbiome in chronic obstructive pulmonary disease (COPD) remains largely unexplored. We present a landscape of airway microbe-host interactions in COPD by an in-depth profiling of sputum metagenome, metabolome, host transcriptome and proteome from 99 COPD pati...

2022-06-20 | MTBLS4017 | MetaboLights

Airway Epithelial miRNA Expression in Asthma

We performed genome-wide profiling of miRNA expression in the airway epithelial compartment in asthma to identify miRNA pathways associated with epithelial abnormalities using miRNA microarrays and real-time PCR. We also sought to identify the effect of inhaled corticosteroids (ICS) on airway epithe...

ORGANISM(S): Homo sapiens

2012-12-05 | E-GEOD-34466 | biostudies-arrayexpress

Effects of Myb shRNA on Airway Epithelial Cells

The epithelium of the pulmonary airway is specially differentiated to provide defense against environmental insults, but also subject to dysregulated differentiation that results in lung disease. The current paradigm for airway epithelial differentiation is a one-step program whereby a p63+ basal ep...

ORGANISM(S): Mus musculus

2014-08-12 | E-GEOD-60365 | biostudies-arrayexpress

Transcription profiling of human airway epithelial cells before and after segmental allergen challenge to identify effects of allergen challenge on airway epithelial cell gene expression

Allergen exposure induces the airway epithelium to produce chemoattractants, proallergic interleukins, matrix-modifying proteins, and proteins that influence the growth and activation state of airway structural cells. These proteins, in turn, contribute to the influx of inflammatory cells and change...

ORGANISM(S): Homo sapiens

2007-11-21 | E-GEOD-3004 | biostudies-arrayexpress

Gene Expression Effects of IL-13 on Primary Human Airway Epithelial Cells

Primary culture airway epithelial cells, grown under physiologic air-liquid interface conditions, with, or without IL-13 in order to study the effects of this cytokine on mucous cell metaplasia, an important feature of asthma and COPD. Keywords: IL13, mucus, goblet cell RNA was isolated from primary...

ORGANISM(S): Homo sapiens

2012-12-04 | E-GEOD-37693 | biostudies-arrayexpress

Transcription profiling of human intra-pulmonary airways and buccal mucosa to identify the effects of cigarette smoke on the human airway epithelial cell transcriptome

A number of studies have shown that cigarette smoking produces a field defect, such that genetic mutations induced by smoking occur throughout the lung and its intra and extra-pulmonary airways. Based on this concept, we have begun this study, which has as its goal the definition of the normal airwa...

ORGANISM(S): Homo sapiens

2007-10-04 | E-GEOD-994 | biostudies-arrayexpress

Transcription profiling of human airway epithelium, large airways, phenotypically normal smokers vs non-smokers, MAS5 (HuGeneFL)

Upregulation of Expression of the Ubiquitin Carboxyl Terminal Hydrolase L1 Gene in Human Airway Epithelium of Cigarette Smokers; The microarray data deposited here is from 44 HuGeneFL GeneChips, from 9 normal non-smokers and 13 phenotypic normal smokers, large airways, 2 samples per individual, one ...

ORGANISM(S): Homo sapiens

2008-11-07 | E-GEOD-5056 | biostudies-arrayexpress

Inflammatory activation of airway epithelial cells by pyocyanin

Despite the appreciated in vivo role of the redox-active Pseudomonas virulence factor pyocyanin in Pseudomonas airway infections and the recognized importance of airway epithelial cells in combating bacterial pathogens, little is known about pyocyaninM-bM-^@M-^Ys effect on airway epithelial cells. W...

ORGANISM(S): Homo sapiens

2011-06-01 | E-GEOD-22430 | biostudies-arrayexpress

Transcription profiling of human airway epithelial cell-conditioned monocyte-derive dendritic cells

Dendritic cells differentiate from their precursors in the airway mucosa under local environmental instruction. Airway epithelial cells (AEC) are a potent source of both pro- and anti-inflammatory mediators and are in intimate contact with intraepithelial DC and their precursors. Thus, AEC are like...

ORGANISM(S): Homo sapiens

2008-10-25 | E-GEOD-12773 | biostudies-arrayexpress

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