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GenomicsGenome Wide Profiling of p53 Response to Differentiation or DNA Damage of Human Embryonic Stem Cells
Tumor suppressor p53 promotes differentiation of human embryonic stem cells (hESCs), but an in-depth understanding of mechanism is lacking. Here, we define p53 functions in hESCs by genome wide profiling of p53 chromatin interactions and intersection with gene expression during early differentiation...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-39912 | biostudies-arrayexpress
TranscriptomicsGenome Wide Profiling of p53 Response to Differentiation or DNA Damage of Human Embryonic Stem Cells
Tumor suppressor p53 promotes differentiation of human embryonic stem cells (hESCs), but an in-depth understanding of mechanism is lacking. Here, we define p53 functions in hESCs by genome wide profiling of p53 chromatin interactions and intersection with gene expression during early differentiation...
ORGANISM(S): Homo sapiens 
2013-10-18 | E-GEOD-39762 | biostudies-arrayexpress
TranscriptomicsEpigenetic profiling of well differentiated and dedifferentiated liposarcoma identifies H3K9me3 and Kruppel-like factor 6 (KLF6) as determinants of aggressiveness in sarcoma (expression)
Little is known about the epigenomics of liposarcoma (LPS). Here, we profiled the global expression of 9 epigenetic marks in well differentiated (WD) and dedifferentiated (DD) LPS from 151 patients and found increased H3K9me3 among DDLPS tumors. We performed ChIP-seq and gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-57750 | biostudies-arrayexpress
GenomicsEpigenetic profiling of well differentiated and dedifferentiated liposarcoma identifies H3K9me3 and Kruppel-like factor 6 (KLF6) as determinants of aggressiveness in sarcoma (ChIP-seq)
Little is known about the epigenomics of liposarcoma (LPS). Here, we profiled the global expression of 9 epigenetic marks in well differentiated (WD) and dedifferentiated (DD) LPS from 151 patients and found increased H3K9me3 among DDLPS tumors. We performed ChIP-seq and gene expression profiling ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-57749 | biostudies-arrayexpress
GenomicsDual roles of RNF2 in melanoma progression [ChIP-seq]
Epigenetic regulators have emerged as critical factors governing the biology of cancer. Here, in the context of melanoma, we show that RNF2 is prognostic, exhibiting progression-correlated expression in human melanocytic neoplasms. Through a series of gain of function and loss of function studies, w...
ORGANISM(S): Homo sapiens 
2016-07-03 | E-GEOD-51929 | biostudies-arrayexpress
GenomicsChromatin enrichment of TRIM24, estrogen receptor and H3K4me2 in estrogen-treated and -untreated MCF7 cells
TRIM24 PHD-Bromo domains exhibit preferential binding to unmethylated H3K4 and acetylated H3K27. TRIM24 is a co-activator of estrogen receptor (ER). The results suggest that specific ER-binding sites are depleted of H3K4me2 with estrogen treatment. TRIM24 binds these sites preferentially and faci...
ORGANISM(S): Homo sapiens 
2010-09-17 | E-GEOD-24166 | biostudies-arrayexpress
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