Sort   by:  
 Page size 
OtherAKT1 AND AKT2 INDUCE DISTINCT PHOSPHORYLATION PATTERNS IN HL-1 CARDIAC MYOCYTES.
Data from ProteomeXchange, PXD ID: PXD000268. Experiment: DML2, file: folder summary. Published as part of J Proteome Res. 2014 Aug 27 . From the Abstract: {{i}} ... To gain more insight into AKT isoform specific signaling at the molecular level we investigated the phosphoproteome of HL-1 cardiomyo...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310003337 | GPMDB
Resource Reanalysis 
TranscriptomicsTranscription profiling of prostate cancer cells with Akt activation
To determine which genes may be regulated by Akt and participate in the transformation of cells, we have examined by microarray analyses genes turned on in the prostate cancer cell line, PC3, when Akt activity was induced. PC3 cells, which lack the lipid phosphatase PTEN, were treated overnight with...
ORGANISM(S): Homo sapiens 
2005-10-11 | E-SMDB-2030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse prostate from AKT transgenic or wild type littermate controls treated with RAD001 (MTOR inhibition) or placebo reveals mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways reveals
Transgenic (Probasin driven Myr-AKT)or wild-type littermates were treated with RAD001 or placebo and sacrificed at 12 and 48 hours following the beginning of treatment
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1413 | biostudies-arrayexpress
ProteomicsEndoxifen Downregulates AKT Phosphorylation Through Protein Kinase C Beta 1 in ER+/HER2- Breast Cancer
In phase I/II clinical trials, Z-endoxifen demonstrated substantial oral bioavailability and promising antitumor activity in endocrine-refractory estrogen-receptor positive breast cancer (ER+ BC) and other solid tumors, with plasma concentrations reportedly as high as 5 ï�M. Therefore, we explored t...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035007 | Pride
Breast cancer Endoxifen Mass spectrometry Pkc-beta-1 Akt Apoptosis Phosphoproteome 
ProteomicsGlutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling
AKT signaling pathway plays critical roles in the resolution of inflammation. However, the underlying mechanisms of anti-inflammatory regulation and signal coordination remain unclear. Here, we report that anti-inflammatory AKT signaling is coordinated by glutamyl-prolyl-tRNA synthetase 1 (EPRS1). U...
ORGANISM(S): Homo sapiens (Human) 
2022-10-12 | PXD036072 | Pride
Aminoacyl-trna synthetase Glutamyl-prolyl-trna synthetase 1 Phosphatidylinositol 3-phosphate Pi3k/akt signaling pathway Multi-trna synthetase complex Inflammation Anti-inflammatory signaling complex Early endosome 
TranscriptomicsExpression data from control and Phospholipid dependent kinase 1 (PDK1) null cytotoxic T-lymphocytes (CTL) and from control and Akt inhibitor treated CTL
In cytotoxic T cells (CTL), Protein Kinase B /Akt is activated by the T cell antigen receptor (TCR) and the cytokine Interleukin 2 (IL2), in part by phosophorylation of Akt by Phospholipid dependent kinase 1 (PDK1). The role of PDK1 and Akt in CTL has however not been fully defined. In order to expl...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-26290 | biostudies-arrayexpress
GenomicsEffects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma
Effects of AKT/WEE1 inhibitors or ALDH inhibitor combined with PD-1 antibody on melanoma
PRJNA818337 | ENA
ProteomicsNaringenin targets PI3K p85alpha to suppress PI3K/AKT signaling pathway and ameliorate disordered MMP-9 secretion in cigarette smoke extract-induced alveolar macrophages in vitro
Naringenin has demonstrated potential therapeutic effects against cigarette smoke-induced lung injury; however, its underlying mechanisms of regulating matrix metalloproteinase-9 (MMP-9) in alveolar macrophages remain unclear. Methods: The regulatory mechanisms of naringenin in cigarette smoke extra...
ORGANISM(S): Mus Musculus 
2025-04-21 | PXD063137 |
GenomicsNDR1 promotes osteoblast differentiation via PI3K-AKT signaling and Beclin-1‑associated autophagy
NDR1 promotes osteoblast differentiation via PI3K-AKT signaling and Beclin-1‑associated autophagy
PRJNA1457520 | ENA
TranscriptomicsElevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: Implications for prostate cancer progression
Background: Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cance...
ORGANISM(S): Homo sapiens 
2010-08-10 | E-GEOD-20956 | biostudies-arrayexpress
Sort   by:  
 Page size