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TranscriptomicsGene expression profiles elicited by estradiol and endoxifen in MCF7 parental and ER-beta expressing breast cancer cells
We have previously demonstrated that endoxifen is the most important tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha. However, the relevance of estrogen receptor-beta in mediating endoxifen action has ...
ORGANISM(S): Homo sapiens 
2011-02-18 | E-GEOD-27375 | biostudies-arrayexpress
ProteomicsEndoxifen Downregulates AKT Phosphorylation Through Protein Kinase C Beta 1 in ER+/HER2- Breast Cancer
In phase I/II clinical trials, Z-endoxifen demonstrated substantial oral bioavailability and promising antitumor activity in endocrine-refractory estrogen-receptor positive breast cancer (ER+ BC) and other solid tumors, with plasma concentrations reportedly as high as 5 ï�M. Therefore, we explored t...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD035007 | Pride
Breast cancer Endoxifen Mass spectrometry Pkc-beta-1 Akt Apoptosis Phosphoproteome 
GenomicsAntitumor Activity of Z-endoxifen in Aromatase Inhibitor-Sensitive and Resistant Estrogen Receptor-Positive Breast Cancer
Antitumor Activity of Z-endoxifen in Aromatase Inhibitor-Sensitive and Resistant Estrogen Receptor-Positive Breast Cancer
PRJNA612349 | ENA
GenomicsDevelopment and characterization of a novel endoxifen-resistant breast cancer cell line highlights numerous differences from tamoxifen-resistant models.
Development and characterization of a novel endoxifen-resistant breast cancer cell line highlights numerous differences from tamoxifen-resistant models.
PRJNA691063 | ENA
TranscriptomicsDevelopment and characterization of a novel endoxifen-resistant breast cancer cell line highlights numerous differences from tamoxifen-resistant models.
Despite the availability of effective drugs that target ERα-positive breast cancer, resistance commonly occurs, resulting in relapse, metastasis, and death. Tamoxifen remains the most commonly-prescribed endocrine therapy worldwide, and “tamoxifen resistance” has been extensively studied. However, l...
ORGANISM(S): Homo sapiens 
2021-01-11 | GSE164529 | GEO
UnknownCYP2D6 genotype- and endoxifen-guided tamoxifen dose escalation increases endoxifen serum concentrations without increasing side effects.
Not available
S-EPMC4589558 | biostudies-literature
TranscriptomicsGene expression profiles elicited by estradiol and endoxifen in MCF7 parental and ER-beta expressing breast cancer cells
We have previously demonstrated that endoxifen is the most important tamoxifen metabolite responsible for eliciting the anti-estrogenic effects of this drug in breast cancer cells expressing estrogen receptor-alpha. However, the relevance of estrogen receptor-beta in mediating endoxifen action has y...
ORGANISM(S): Homo sapiens 
2011-02-18 | GSE27375 | GEO
UnknownSkeletal and Uterotrophic Effects of Endoxifen in Female Rats.
Not available
S-EPMC5659691 | biostudies-literature
TranscriptomicsAntitumor Activity of Z-endoxifen in Aromatase Inhibitor-Sensitive and Resistant Estrogen Receptor-Positive Breast Cancer
The overarching goal of this study was to explore the antitumor activity of Z-endoxifen, a tamoxifen metabolite, with first-line endocrine therapies tamoxifen and letrozole in the letrozole-sensitive MCF7 aromatase expressing model (MCF7AC1), and with second-line endocrine therapies including tamoxi...
ORGANISM(S): Homo sapiens 
2020-03-13 | GSE146911 | GEO
UnknownEndoxifen, an Estrogen Receptor Targeted Therapy: From Bench to Bedside.
Not available
S-EPMC8787422 | biostudies-literature
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