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ProteomicsProteomics profiling to distinguish DOCK8 deficiency from atopic dermatitis
Background: DOCK8 deficiency is an autosomal recessive form of hyperimmunoglobulinemia E syndrome (HIES). Severe atopic dermatitis (AD) shares with DOCK8 deficiency some clinical symptoms, including eczema, eosinophilia, and increased serum IgE levels. The deficiency of DOCK8 protein is potentially ...
ORGANISM(S): Homo sapiens (Human) 
2022-05-17 | PXD029052 | Pride
Atopic dermatitis Multiple-reaction monitoring Label-free proteomics Lc-mse synaptg2 Dedicator of cytokinesis (dock8) Hyper ige syndrome (hies) 
Proteomicshttps://edelivery.oracle.com/akam/otn/java/jdk/8u202-b08/1961070e4c9b4e26a04e7f5a083f551e/jre-8u202-windows-i586-iftw.exe
This study examines how aging influences the proteomic landscape of human spermatozoa. Proteomic analysis was done on sperm samples from three groups of normal, fertile men: young adults (21–30 years), late adults (31–40 years), and advanced age (41–51 years). The analysis revealed dynamic age-relat...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD062650 | Pride
Proteomics Lc-ms/ms. Human Aging Spermatozoa 
Proteomicsproteotoxic stress response in in-vitro 2 human neuronal models 3
We used an untargeted pro-24 teomic approach using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to identify 25 and characterize time-series proteome-wide changes in dose-responsive mild and extreme proteo-26 toxic stress models in medulloblastoma [Daoy], neuroblastoma [SH-SY5Y] and diff...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD051826 | Pride
Neurons  proteostasis  heat shock  proteotoxic stress  stress response  proteomics 
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