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TranscriptomicsMolecular anatomy of gene expression responses in stressed hepatocytes
It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in live...
ORGANISM(S): Mus musculus 
2016-09-28 | E-MTAB-4444 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells in matrigel and recombinant laminins
Stem cell derived somatic cells represent an unlimited resource for basic and translational science. While promising, there are significant hurdles that must be overcome. Our focus is on the generation of the major cell type of the human liver, the hepatocyte. Current protocols produce variable pop...
ORGANISM(S): Homo sapiens 
2016-01-18 | E-MTAB-3994 | biostudies-arrayexpress
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
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