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TranscriptomicsAML1/ETO binding pattern on human promoters
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used microarrays to id...
ORGANISM(S): Homo sapiens 
2008-12-21 | E-GEOD-10531 | biostudies-arrayexpress
TranscriptomicsAnalysis of expression levels of genes on chromosome 19 in U937 cells expressing AML1/ETO
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used ChIP-chip to iden...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10579 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of blasts from three APL patients expressing PML/RAR before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours
Gene expression profiles in blasts from three APL patients expressing PML/RAR were assessed before and after treatment with 1 uM retinoic acid (RA) in vitro for four hours. We then studied a U937 clone conditionally expressing PML/RAR (U937-PR), (Grignani et al. 1993) (Alcalay et al. 2003), and comp...
ORGANISM(S): Homo sapiens 
2004-12-31 | E-MEXP-149 | biostudies-arrayexpress
TranscriptomicsAML1/ETO, AML1, and HEB binding patterns on chromosme 19
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used ChIP-chip to iden...
ORGANISM(S): Homo sapiens 
2008-11-27 | E-GEOD-10578 | biostudies-arrayexpress
TranscriptomicsGenes regulated after knock-down of Pirin in U937 cells
Pirin (PIR) is a putative transcriptional regulator whose expression is silenced in cells bearing the AML1/ETO and PML/RAR leukemogenic fusion proteins and is significantly repressed in a large proportion of acute myeloid leukemias. PIR expression increases during in vitro myeloid differentiation of...
ORGANISM(S): Homo sapiens 
2009-12-10 | E-GEOD-16798 | biostudies-arrayexpress
TranscriptomicsGenes regulated in EML1 cells expressing the TEL-AML1 oncogene after 5 and 7 days of treatment with IL7 and FLT3 ligand.
The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene, which functions as a transcription factor. TEL-AML1 expression in EML1 cells results in an impairment of differentiation along the B-lymphoi...
ORGANISM(S): Mus musculus 
2015-05-13 | E-GEOD-64919 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human U937 cells expressing AML1/ETO compared to vector transfected U937 cells to identify genes regulated by AML1/ETO
Approximately 20% of Acute Myelogenous Leukemia (AML) cases carry the t(8;21) translocation, which involves the AML1 and ETO genes, and express the resulting AML1/ETO fusion protein that functions as a transcriptional repressor by recruiting NCoR/SMRT/HDAC complexes to DNA. We used microarrays to id...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-10520 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human osteosarcoma U2OS cell line conditionally expressing HA-tagged PRDM5
PRDM5 is a recently identified member of the PRDM family of proteins, which functions as a transcriptional repressor by recruiting histone methyltransferase G9A to DNA, and behaves as a putative tumor suppressor in different types of cancer. We investigated PRDM5 function by identifying its target g...
ORGANISM(S): Homo sapiens 
2009-01-31 | E-GEOD-10580 | biostudies-arrayexpress
TranscriptomicsGene expression profile and DNA binding pattern of AML1/ETO in U937 cells
This SuperSeries is composed of the following subset Series: GSE10520: Genes regulated by AML1/ETO in U937 cells GSE10537: Gene expression profiling of AML1/ETO regulated genes and binding pattern on human promoters in U937 cells GSE10578: AML1/ETO, AML1, and HEB binding patterns on chromosme 19 GSE...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10537 | biostudies-arrayexpress
GenomicsPAT-ChIP-Seq: a novel tool for the epigenetic profiling of formaldehyde-fixed and paraffin-embedded (FFPE) pathology samples
Epigenetic alterations in the pattern of DNA and histone modifications play a crucial role in cancer development. Analysis of patient samples, however, is hampered by technical limitations in the study of chromatin structure from pathology archives that typically consist of heavily fixed, paraffin-e...
ORGANISM(S): Mus musculus 
2010-12-02 | E-GEOD-21449 | biostudies-arrayexpress
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