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MetabolomicsPharmacological Targeting of ALDH1a2 in Dendritic Cells Enhances Antigen Presentation, T Cell Activation and Anti-tumor immunity
Dendritic cell (DC) vaccines have been proposed as cancer immunotherapies due to their role as crucial antigen-presenting cells that regulate T cell functions. Despite considerable efforts to optimize ex vivo priming of DCs, DC vaccines have rarely been successful, suggesting the presence of unknown...
2025-11-03 | MTBLS10389 | MetaboLights
TranscriptomicsMolecular mechanism underlying increased ischemic damage in the ALDH2*2 genetic polymorphism using a human iPSC model system
We investigated the ALDH2*2 genetic polymorphism and its underlying mechanisms for the first time in a human model system of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from individuals carrying the most common heterozygous form of the ALDH2*2 genotype. We showed that t...
ORGANISM(S): Homo sapiens 
2014-07-07 | E-GEOD-59100 | biostudies-arrayexpress
TranscriptomicsPKCepislon-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation
ALDH2 activator, Alda-1, is able to increase the catalytic activity of ALDH2. ALDH2 expression negatively correlates with obesity in mice while 4-HNE accumulation is positively associated with obesity and is increased in terminal adipocyte differentiation. We compared the difference of transcription...
ORGANISM(S): Mus musculus 
2016-09-07 | E-MTAB-4936 | biostudies-arrayexpress
GenomicsSequencing of Aldh2-/- Adh5-/- mouse HSPC clones
Sequencing of haematopoietic stem and progenitor cell clones from Aldh2-/- Adh5-/- mice
PRJEB40375 | ENA
ProteomicsProteomic analysis of mitochondria isolated from the frontal cortex and hippocampus of apolipoprotein E knockout mice treated with Alda-1, an activator of mitochondrial aldehyde dehydrogenase (ALDH2)
Recently, it has been shown that mitochondrial dysfunction and oxidative stress play important roles in the pathogenesis of neurodegeneration. Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes – the end products of lipid peroxidation, i...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-23 | PXD004022 | Pride
Alzheimer’s disease Brain Aldh2 Mitochondria Apolipoprotein e 
GenomicsExpression data from ALDH2 knockdown in head and neck cancer cells.
Expression data from ALDH2 knockdown in head and neck cancer cells.
PRJNA1066363 | ENA
ProteomicsA common East Asian-specific ALDH2 mutation causes obesity and insulin resistance: therapeutic effect of reducing toxic aldehydes by ALDH2 activation
Obesity and type 2 diabetes have reached pandemic proportion. In particular, the population with diabetes is expected to rise rapidly in East and South Asia. ALDH2 (acetaldehyde dehydrogenase 2, mitochondrial) is the key metabolizing enzyme of acetaldehyde and other toxic aldehydes, such as 4-hydrox...
ORGANISM(S): Mus Sp. (ncbitaxon:10095) 
2023-04-16 | MSV000091724 | MassIVE
GenomicsALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility
ALDH2 inhibition reprograms tubular epithelial cell metabolism and promotes renal injury susceptibility
PRJNA1312710 | ENA
GenomicsCharacterization of ALDH2-deficient alcohol-associated liver disease (duodenum RNA seq)
Characterization of ALDH2-deficient alcohol-associated liver disease (duodenum RNA seq)
PRJNA1215761 | ENA
ProteomicsProteome profiling of N2a pretreated with ALDH2
Aldehyde dehydrogenase 2 family member (ALDH2) is a key mitochondrial dehydrogenase that functions in the detoxification of acetaldehyde, and endogenous 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde generated by polyunsaturated fatty acid peroxidation. In this study, we found that altered ALDH2 en...
ORGANISM(S): Mus Musculus 
2023-11-24 | PXD047209 |
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