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ProteomicsComposition of Rosenthal fibers in Alexander disease patients and mouse models
Alexander disease (AxD) is a fatal neurodegenerative disorder characterized by the presence in astrocytes of protein aggregates called Rosenthal fibers (RFs). In this work, we used a new biochemical fractionation method to enrich for RFs followed by analysis of this fraction using quantitative iTRA...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2016-05-23 | PXD002448 | Pride
Alexander disease Rosenthal fibers Itraq 8-plex 
TranscriptomicsHDAC inhibition by TSA and Butyrate In Flt3L-elicited DC
Butyrate induces Treg via HDACi activity Microarray of DC treated with TSA or Butyrate over untreated
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-51263 | biostudies-arrayexpress
UnknownComposition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease.
Not available
S-EPMC5036859 | biostudies-literature
TranscriptomicsTranscription profiling of different sub-types of mouse dendritic cells to study the functional relationships and properties of these cells.
The functional relationships and properties of different sub-types of dendritic cells (DC) remain largely undefined. We used a global gene profiling approach to determine gene expression patterns among murine splenic CD11c high DC subsets in an effort to better characterise these cells.
ORGANISM(S): Mus musculus 
2007-09-11 | E-GEOD-339 | biostudies-arrayexpress
GenomicWhole Genome Study for De Novo Mutation Rates

Germline mutations are the source of evolution and contribute substantially to many health-related processes. In this study, we use whole genome deep sequencing data from parents-offspring trios to examine the de novo point mutations (DNMs) in the offspring.

We studied correlation between ...

phs001055 | dbGaP
TranscriptomicsC/EBPalpha regulated microRNA expression profiling in inducible K562-C/EBPalpha-ER cells
C/EBPalpha is an important myeloid transcription factor that is inactivated in approximately 50% of acute myeloid leukemia cases. We were interested in microRNAs that are regulated by C/EBPalpha during myeloid differentiation. We induced K562-C/EBPalpha-ER cells for 6 hours with 5µM ß-estradiol or...
ORGANISM(S): Homo sapiens 
2017-04-28 | E-GEOD-72634 | biostudies-arrayexpress
MetabolomicsRapid UHPLC-MS metabolite profiling and phenotypic assays reveal genotypic impacts of nitrogen supplementation in oats
INTRODUCTION: Oats (Avena sativa L.) are a whole grain cereal recognised for their health benefits and which are cultivated largely in temperate regions providing both a source of food for humans and animals, as well as being used in cosmetics and as a potential treatment for a number of...
2020-06-11 | MTBLS804 | MetaboLights
TranscriptomicsA role for Multidrug Resistance Protein 4 (MRP4; ABCC4) in human Dendritic Cell migration.
The capacity of dendritic cells (DC) to migrate from peripheral organs to lymph nodes (LN) is an important event in the initiation of a T cell-mediated immune response. Previously it was shown that the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp; ABCB1) and the 2 multidrug resistanc...
ORGANISM(S): Homo sapiens 
2008-07-12 | E-GEOD-12089 | biostudies-arrayexpress
TranscriptomicsThe lifespan and kinetics of human Dendritic Cell subsets and their precursors in health and inflammation
To probe the phenotype of the cDC compartment during pathology, we developed a simplified human experimental skin blister model to sample infiltrating cells in order to examine the function and kinetics of DC populations in response to a bacterial insult in healthy individuals. ASDC were recruited t...
ORGANISM(S): Homo sapiens 
2024-09-24 | E-MTAB-14451 | biostudies-arrayexpress
MetabolomicsAssessing the impact of nitrogen supplementation in oats across multiple growth locations and years with targeted phenotyping and high-resolution metabolite profiling approaches
Oats (Avena sativa L.) are a healthy food, being high in dietary fibre (e.g. β-glucans), antioxidants, minerals, and vitamins. Understanding the effect of variety and crop management on nutritional quality is important. The response of four oat varieties to increased nitrogen levels was investigated...
2021-04-26 | MTBLS1801 | MetaboLights
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