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ModelsImam2011_RhodobacterSphaeroides_MetabolicNetwork
This model is from the article: iRsp1095: A genome-scale reconstruction of the Rhodobacter sphaeroides metabolic network Imam S, Yilmaz S, Sohmen U, Gorzalski AS, Reed JL, Noguera DR, Donohue TJ. BMC Syst Biol. 2011 Jul 21;5:116. 21777427 ...
2005-01-01 | MODEL1106220000 | BioModels
UnknownGene correction of HBB mutations in CD34+ hematopoietic stem cells using Cas9 mRNA and ssODN donors.
Not available
S-EPMC6236008 | biostudies-literature
ProteomicsChemoproteomic Profiling by Cysteine Fluoroalkylation Reveals the DNA Repair Protein XRCC5 as a Functional Target of Myrocin G
Chemoproteomic profiling of cysteines has emerged as a powerful method for screening the proteome-wide targets of cysteine-reactive frag-ments, drugs and natural products. Herein, we report the development and an in-depth evaluation of a tetrafluoroalkyl benziodoxole as a cyste-ine-selective chemopr...
ORGANISM(S): Homo sapiens (Human) 
2021-12-13 | PXD029255 | Pride
Human Q exactive hf-x Natural product Hypervalent iodine Target id Myrocin 
TranscriptomicsModeling Formamide Denaturation of Probe-Target Hybrids for Improved Microarray Probe Design in Microbial Diagnostics
This study aimed to model formamide-based melting for the optimization of the sensitivity and specifcity of oligonucleotide probes in dignostic high-density microarrays. Formamide melting profiles of DNA oligonucleotides were obtained with a high-density microarray targeting 16S rRNA genes of Escher...
ORGANISM(S): Rhodobacter sphaeroides 2.4.1 
2012-06-29 | E-GEOD-33021 | biostudies-arrayexpress
ProteomicsProteomics, post-translational modifications, and integrative analyses reveal heterogeneity of molecular mechanisms within medulloblastoma subgroups
Archer TC, Ehrenberger T, Mundt F, Gold MP, Krug K, Mah CK, Mahoney EL, Daniel CJ, LeNail A, Ramamoorthy D, Mertins P, Mani DR, Zhang H, Gillette MA, Clauser K, Noble M, Tang LC, Francois JP, Silterra J, Jensen J, Tamayo P, Korshunov A, Pfister SM, Kool M, Northcott PA, Sears RC, Lipton JO, Carr SA,...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-07-20 | MSV000082644 | MassIVE
ProteomicsEthynylation of Cysteines from Peptides to Proteins in Living Cells
Efficient methods to introduce bioorthogonal groups, such as terminal alkynes, into biomolecules are important tools for chemical biology. State-of-the-art approaches are based on the introduction of a linker between the targeted amino acid and the alkyne, and still present limitations of either rea...
ORGANISM(S): Homo sapiens (Human) 
2020-04-07 | PXD018165 | Pride
Human Qexactive hf-x Cysteine ethynylation Hela 
ProteomicsSolid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows
Macrocyclic peptides are attractive for chemoproteomic applications due to their modular synthesis and potential for high target selectivity. We describe a solid phase synthesis method for the efficient generation of libraries of small macrocycles that contain an electrophile and alkyne handle. The ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-02 | PXD039931 | Pride
Sufex Chemoproteomics Electrophile Macrocycles Fluorosulfate 
Proteomics1-deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding
Ischemic heart disease and stroke are the most common causes of death world-wide. In both pathologies anoxia, the lack of oxygen, triggers profound metabolic and cellular changes. Sphingolipids have been implicated in anoxia injury, but the pathomechanism is unknown. Here we show that injury is caus...
ORGANISM(S): Caenorhabditis elegans 
2019-08-20 | PXD014573 | Pride
C. elegans Qexactive plus Lc-ms/ms 
ProteomicsMixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets
Malaria, caused by Plasmodium falciparum, remains a significant health burden. The barrier for developing anti-malarial drugs is the ability of the parasite to rapidly generate resistance. We previously demonstrated that Salinipostin A (SalA), a natural product, potently kills parasites by inhibitin...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2024-07-15 | PXD051499 | Pride
Plasmodium Lipid metabolism Serine hydrolases Activity-based probes 
TranscriptomicsSpatio-temporal transcriptome of the human brain
The development of the human brain is a complex and precisely regulated process that unfolds over a protracted period of time. Human-specific features of this process, especially the ways in which highly complex neural circuits of the cerebral cortex form, are likely to be important factors in the e...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-25219 | biostudies-arrayexpress
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