Chronic metabolic acidosis occurs commonly in patients with diseased kidneys and is linked with progression to renal failure. As renal function declines there is loss of nephron mass and adaptive proximal tubular hypertrophy and hypermetabolism. We have previously demonstrated in an in vitro model o...
This is system 1, the model with linear antigen uptake by pAPCs, described in the article:
Self-tolerance and Autoimmunity in a Regulatory T Cell Model.
Alexander HK, Wahl LM.
Bull Math Biol. 2010 Mar 2.
PMID:20195912, doi:10.1007/s11538-010-95...
This is system 2, the model with Michelis Menten type antigen uptake by pAPCs, described in the article:
Self-tolerance and Autoimmunity in a Regulatory T Cell Model.
Alexander HK, Wahl LM. Bull Math Biol.
2010 Mar 2.
PMID: ...
S. aureus possesses 16 two-component systems (TCS), two of which (GraRS & NsaRS) belong to the intramembrane-sensing histidine kinase (IM-HK) family, conserved within the firmicutes. NsaRS has recently been documented as being important for nisin-resistance in S. aureus. In this study we present a d...
