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ProteomicsIncreased cysteine protease activity in the aphid midgut decreases the transmission efficiency of a circulative plant virus
Aphids, sap-sucking insects in the order Hemiptera, are among the most prolific insect vectors of plant viruses Plant viruses from the family Luteoviridae are transmitted exclusively by aphids in a circulative manner and cause significant crop yield losses. Circulative plant viruses must cross the a...
ORGANISM(S): Myzus persicae persicae 
2016-12-14 | PXD004893 | Pride
Host-pathogen interactions Lc-msms Luteoviridae Potato leafroll virus 2d-dige 
GenomicsMouse ooplasm confers context-specific reprogramming capacity
Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and identify specific targets for DNA demethylation as well as NT specific limitations. We find that the ooplasm can confer...
ORGANISM(S): Mus musculus 
2012-08-10 | E-GEOD-38711 | biostudies-arrayexpress
GenomicsDNA methylation dynamics of the human pre-implantation embryo
We present genome-scale maps of DNA methylation in early human development and perform comparative analysis to mouse that confirm a conserved global erasure of the paternal genome. We find that while many global features of the early embryo are consistent between the two species, the target sequenc...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-51239 | biostudies-arrayexpress
GenomicsA unique regulatory phase of DNA methylation in the early mammalian embryo
DNA methylation is highly dynamic during mammalian embryogenesis. It is broadly accepted that the paternal genome is actively depleted of global cytosine methylation at fertilization, followed by passive depletion that reaches a minimum at the blastocyst stage. However, this model is based on limit...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-34864 | biostudies-arrayexpress
GenomicsAS
WTCCC2 project samples from Ankylosing spondylitis Cohort
EGAD00010000150 | EGA
GenomicsGenomewide association studies in ankylosing spondylitis
The aim of this study was to identify genes associated with ankylosing spondylitis susceptibility in British and Australian individuals of European descent.
EGAS00000000104 | EGA
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