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UnknownSpace-associated stem cell hallmarks of aging and resilience in astronauts.
Not available
S-EPMC12826796 | biostudies-literature
MetabolomicsGeographic variation of mutagenic exposures in kidney cancer genomes

International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not been identified by conventional epidemiology yet potentially make a substantial contribution to cancer burden1. This pertains to clear cell renal cell carcinoma (ccRCC), fo...

2024-03-26 | MTBLS9394 | MetaboLights
GenomicsExome-sequencing identifies new oncogenes and tumor suppressor genes recurrently altered in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. High-resolution copy number analysis of 125 tumors of which 24 were subjected to whole-exome sequencing identified 135 homozygous deletions and 994 somatic gene mutations with predicted functional consequences. We identified...
EGAS00001000217 | EGA
UnknownExome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
Not available
S-EPMC4587544 | biostudies-literature
UnknownRAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.
Not available
S-EPMC3960636 | biostudies-literature
GenomicsExome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
Genomic analyses promise to improve tumor characterization in order to optimize personalized treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of 243 liver tumors revealed mutational signatures associated with specific risk factors, mainly combined alcohol/tobacco...
EGAS00001001002 | EGA
GenomicsIntegrative genomic profiling of hepatocellular adenomas reveals recurrent FRK activating mutations and mutational processes of malignant transformation
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in women using oral contraception. Here, exome sequencing identified novel recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation and cell proliferation sensitive to Src inhibitors. We a...
EGAS00001000679 | EGA
UnknownTracing Lung Cancer Risk Factors Through Mutational Signatures in Never-Smokers.
Not available
S-EPMC8316614 | biostudies-literature
UnknownNanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.
Not available
S-EPMC12764381 | biostudies-literature
UnknownUncovering novel mutational signatures by <i>de novo</i> extraction with SigProfilerExtractor.
Not available
S-EPMC9646490 | biostudies-literature
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