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TranscriptomicsGene expression analysis of T-ALL cell lines treated with gamma-secretase inhibitor
Gain-of-function mutations in NOTCH1 are common in T-cell lymphoblastic leukemias making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSI), which block a proteolytic cleavage required for NOTCH1 activation. However, the enthusiasm for these therapies has been temper...
ORGANISM(S): Homo sapiens 
2008-08-20 | E-GEOD-5716 | biostudies-arrayexpress
GenomicsExtensive conservation of ancient microsynteny across metazoans
Gene order, or microsynteny, is generally thought not to be conserved across metazoan phyla. Only a handful of exceptions, typically of tandemly duplicated genes such as Hox genes, have been discovered. Here, we performed a systematic survey for microsynteny conservation in 17 genomes and identified...
ORGANISM(S): Danio rerio 
2012-06-21 | E-GEOD-35050 | biostudies-arrayexpress
TranscriptomicsHigh-throughput pyrosequencing of endogenous small RNAs from Arabidopsis thaliana wild-type and ddm1 mutant.
DNA methylation is essential for silencing transposable elements and some genes in higher eukaryotes, implying that this modification must be tightly controlled. However, accidental changes in DNA methylation can be transmitted through mitosis, as in cancer, or meiosis, leading to epiallelic variati...
ORGANISM(S): Arabidopsis thaliana 
2009-02-02 | E-GEOD-13419 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hematopoietic stem cell subpopulations
Hematopoietic stem cell (HSC) subsets based on the CD34 expression and/or lineage markers expression
ORGANISM(S): Homo sapiens 
2007-08-03 | E-GEOD-1493 | biostudies-arrayexpress
UnknownCombined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.
Not available
S-EPMC5698905 | biostudies-literature
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [beta-catenin organoids]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Mus musculus 
2015-10-26 | E-GEOD-67847 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [LS-174-T]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67846 | biostudies-arrayexpress
TranscriptomicsIdentification of a potent and selective chemical probe for exploring the role of Mediator complex-associated protein kinases CDK8 and CDK19 in human disease [Colo205]
There is an unmet need for chemical tools to explore the role of the Mediator complex in human pathologies ranging from cancer to cardiovascular disease. Here we determine that CCT251545 a WNT-pathway inhibitor discovered by cell-based screening is a potent and selective chemical probe for the Medi...
ORGANISM(S): Homo sapiens 
2015-10-26 | E-GEOD-67845 | biostudies-arrayexpress
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
UnknownGlobal hospital-based disease management of acute diverticulitis: a prospective, international cohort study.
Not available
S-EPMC12512976 | biostudies-literature
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