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Wildtype and Mt1(-/-)Mt2(-/-) double knockout 129S1/SvImJ strain mouse lungs were compared in their response to nickel aerosol exposure at 3, 8, 24, 48, and 72 hrs.
ORGANISM(S): Mus musculus 
Mice with a chromosome substitution from A/J strain were compared to parental strains, and acute lung injury following ozone exposure was measured. The candidate gene identified by microarray and genome-wide scans was tested in knockout and pharmacologically altered mice.
ORGANISM(S): Mus musculus 
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