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GenomicsFunctional link between Rad2 and Mediator
In this study, we generate genomic maps of Mediator, Rad2, Pol II, TBP and TFIIH, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae. A related study involving ChIP-chip analysis of Rad2 occupany is also deposited at ArrayExpress ...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-01 | E-MTAB-1595 | biostudies-arrayexpress
GenomicsAnalyses of Rad2, Mediator and RNA Polymerase II in different yeast mutant context.
We performed ChIP-seq analyses of Rad2, Mediator (Med17 and Med5) and RNA Polymerase II in Kin28-ts16 mutant, Med17-Q444P and Med17-Q444P/M442L mutants and in an Rpb9 deleted strain.
ORGANISM(S): Saccharomyces cerevisiae S288C 
2019-07-01 | E-MTAB-7081 | biostudies-arrayexpress
TranscriptomicsProstaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4
Recognition of foreign antigens by B cell receptor (BCR) on mature B cells leads to their clonal expansion, which is critically important for the effective host defence of the organism. However, excessive antigenic responses or reaction of B cells against body’s own components frequently lead to d...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9847 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of BCR-triggered immature and mature mouse B cells
The B cell antigen receptor (BCR) is a signaling complex that mediates differentiation stage-specific cell fate decisions in B lymphocytes. While several studies have evidenced differences in signal transduction components as being key to contrasting phenotypic outcomes, little is known about the di...
ORGANISM(S): Mus musculus 
2008-12-14 | E-GEOD-9215 | biostudies-arrayexpress
GenomicsFunctional link between TFIIB and Mediator
In this study, we generate genomic maps of Mediator, Pol II, TBP, TFIIH, TFIIA, TFIIB, TFIIE, TFIIF, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type strains from Saccharomyces cerevisiae and in a mutant for the Mediator essential subunit Med10
ORGANISM(S): Saccharomyces cerevisiae 
2017-01-24 | E-MTAB-4607 | biostudies-arrayexpress
GenomicsGenomic binding of Pol III transcription machinery and relationship with TFIIS distribution in mouse embryonic stem cells
RNA polymerase (RNA Pol) III synthesizes the tRNAs, the 5S ribosomal RNA and a small number of untranslated RNAs. In vitro, it also transcribes short interspersed nuclear elements (SINEs). We investigated the distribution of RNA Pol III and its associated transcription factors on the genome of mouse...
ORGANISM(S): Mus musculus 
2011-09-16 | E-MTAB-767 | biostudies-arrayexpress
GenomicsMediator orchestrates PIC assembly
In this study, we generate genomic maps of Mediator, Pol II, TBP and TFIIH, by ChIP coupled to next generation sequencing technology (ChIP-seq), in wild type (WT) strains and med17-ts mutants from Saccharomyces cerevisiae. Some of the data, concerning WT strains are also deposited at ArrayExpress u...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-03 | E-MTAB-2961 | biostudies-arrayexpress
TranscriptomicsRad2 ChIP-chip experiment
This aim of this experiment is to assess the genome-wide Rad2 occupancy in yeast Saccharomyces cerevisiae by ChIP-chip, in the absence of exogenous genotoxic stress. A related study involving ChIP-seq analysis of Rad2 occupany is also deposited at ArrayExpress under accession number E-MTAB-1595 ( ww...
ORGANISM(S): Saccharomyces cerevisiae 
2013-12-01 | E-MEXP-3875 | biostudies-arrayexpress
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