Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human immunoglobulin mutation genotype in B Cell chronic lymphocytic leukaemia
The Journal of Experimental Medicine, Volume 194, Number 11, December 3, 2001 1639-1648 Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia Andreas Rosenwald1, Ash A. Alizadeh2, George Widhopf5, Richard Simon6, R. Eric Davis1, Xin Yu1, ...
ORGANISM(S): Homo sapiens 
2005-06-29 | E-SMDB-1002 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Jurkat T cell line and mouse thymocytes
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligandindependent signaling by the precursors of mature...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-SMDB-2194 | biostudies-arrayexpress
TranscriptomicsAdult T-cell leukemia-lymphoma and AZT-IFNa combination therapy
Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from 9 patients with ATLL at the time of diagnosis and immediately after combination therapy with zidovudine (AZT) ...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19160 | biostudies-arrayexpress
TranscriptomicsLymphomaTransformation
Transformation of Follicular Lymphoma to Diffuse Large Cell Lymphoma: Alternative Patterns with Increased or Decreased Expression of c-myc and its Regulated genes The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large ...
ORGANISM(S): Homo sapiens 
2005-10-18 | E-GEOD-3458 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of follicular lymphoma to diffuse large cell lymphoma
Transformation of Follicular Lymphoma to Diffuse Large Cell Lymphoma: Alternative Patterns with Increased or Decreased Expression of c-myc and its Regulated genes The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large ...
ORGANISM(S): Homo sapiens 
2005-09-23 | E-SMDB-963 | biostudies-arrayexpress
TranscriptomicsBasal Cell Carcinoma Tumor-derived Fibroblasts
Dataset contains samples that are all fibroblast cells that have been cultured from fresh human tissue. Fibroblasts were derived either from tumor (basal cell carcinoma) or non-tumor (control) tissue. Samples were maintained in DMEM, 10% FBS, glutamine, pen/strep and passaged for 4 passages before...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5502 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of diffuse large B-cell lymphoma identifying different subtypes
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history refle...
ORGANISM(S): Homo sapiens 
2005-06-28 | E-SMDB-183 | biostudies-arrayexpress
TranscriptomicsRelation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. La...
ORGANISM(S): Homo sapiens 
2005-08-27 | E-GEOD-3211 | biostudies-arrayexpress
TranscriptomicsIntegrative profiling of follicular lymphoma at diagnosis and relapse
B-cells were purified from cyropreserved tumor cell suspensions by FACS, DNA isolated, and interogated using Affymetrix 250K Nsp SNP microarrays. Aim: To track the evolution of genetic alterations during progression of follicular lymphoma. One array per tumor.
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-56311 | biostudies-arrayexpress
GenomicsClonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the bone marrow that is the direct result of sequential acquisition of mutations in a single lineage of cells. In this study, we investigate a model in which this mutational acquisition occurs serially in long-lived self-renewing hemato...

phs000549.v1.p1 | EGA
Sort   by:  
 Page size