Sort   by:  
 Page size 
TranscriptomicsGene expression profiling of Activin-like kinase 2 knockout in mice
Implantation of an embryo in the uterus is a multistep process tightly controlled by an intricate regulatory network of interconnected ovarian, uterine, and embryonic factors. Bone morphogenetic protein (BMP) ligands and receptors are expressed in the pregnant uterus, and BMP2 has been shown to be a...
ORGANISM(S): Mus musculus 
2014-01-07 | E-GEOD-46689 | biostudies-arrayexpress
ProteomicsStructural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization
Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mechanism of kinase activation, however, has not been e...
ORGANISM(S): Homo sapiens (Human) 
2021-08-16 | PXD022944 | Pride
Bmpr2 Alk2 Hdx-ms 
GenomicsALK2/3 are components of the immune synapse crucial for T cell activation and death
ALK2/3 are components of the immune synapse crucial for T cell activation and death
PRJNA1238328 | ENA
TranscriptomicsALK2/3 are components of the immune synapse crucial for T cell activation and death
Antigen recognition by TCR triggers T cell activation and activation-induced cell death (AICD). To investigate additional mechanisms beyond the classical model of T cell activation and death, we conducted a survival-based kinome-wide CRISPR-Cas9 knockout screens and identified the BMP receptors ALK2...
ORGANISM(S): Homo sapiens 
2025-05-30 | GSE292407 | GEO
TranscriptomicsConcurrent progress of reprogramming and gene-correction to overcome limitation of gene therapy of ALK2 mutant iPSCs
To ameliorate the cumbersome processes of reprogramming and subsequent gene-editing in vulnerable iPSCs, we have developed a greatly simplified one-step procedure, simultaneously introducing reprogramming and gene-editing components into human fibroblast cells. This not only serves to save time, lab...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-68766 | biostudies-arrayexpress
UnknownRecent Advances in ALK2 Inhibitors.
Not available
S-EPMC8374899 | biostudies-literature
UnknownCryoEM structure of ALK2:BMP6 reveals distinct mechanism that allow ALK2 to interact with both BMP and activin ligands.
Not available
S-EPMC12415261 | biostudies-literature
UnknownALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex.
Not available
S-EPMC7911104 | biostudies-literature
UnknownDiscovery of Conformationally Constrained ALK2 Inhibitors.
Not available
S-EPMC10983009 | biostudies-literature
UnknownALK3 undergoes ligand-independent homodimerization and BMP-induced heterodimerization with ALK2.
Not available
S-EPMC6842210 | biostudies-literature
Sort   by:  
 Page size