Sort   by:  
 Page size 
TranscriptomicsAmplicon sequencing of the trp53 locus of DNA extracted from FFPE sections of tumors obtained from the gastrointestinal tract of APC mice
This experiment was done to analyze the p53 status in gastrointestinal tumors in the colon and small intestine in APC mice carrying either a wild type p53 or a mutant p53 (R172H) allele and compare colon and small intestine tumors.
ORGANISM(S): Mus musculus 
2020-02-25 | E-MTAB-8355 | biostudies-arrayexpress
TranscriptomicsIntestinal ablation of CKIalpha highlights invasiveness control
Wnt signaling, which drives the rapid self-renewal of the gut epithelium is causally associated with intestinal neoplasia. Here we show that CKIalpha is a activation depends on p53 and p21Waf1/Cip1: CKIα ablation provokes activation of p53 and p21, which assume a pivotal role in suppressing invasiv...
ORGANISM(S): Mus musculus 
2010-10-23 | E-GEOD-24760 | biostudies-arrayexpress
TranscriptomicsAblation of casein kinase 1 in keratinocytes induces p53-dependent hyperpigmentation of the skin
To characterize the role of CK1 (encoded by Csnk1a1) in skin physiology, we crossed mice with floxed Csnk1a1 with mice expressing K14CreERT2 to generate mice in which tamoxifen induces the deletion of Csnk1a1 exclusively in keratinocytes (SKO). In addition, we established K14CreERT2 CK1/p53 double-k...
ORGANISM(S): Mus musculus 
2017-08-25 | E-MTAB-5442 | biostudies-arrayexpress
Sort   by:  
 Page size