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TranscriptomicsPrednisolone-induced differential gene expression in liver of mice carrying the wild type or a dimerization-defective glucocorticoid receptor
Glucocorticoids control expression of a large number of genes after binding to the glucocorticoid receptor (GR). Transcription may be regulated either by binding of the GR dimer to DNA regulatory elements or by protein-protein interactions of GR monomers with other transcription factors. Although th...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21048 | biostudies-arrayexpress
TranscriptomicsProfiling of Jurkat T cells activated with CD3, CD28 and PMA at 1 and 8 hours
T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into the Th1, Th2, Th17 or iTreg phenotype, depending on environmental co-stimulatory signals. In order to identify the genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes ...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30676 | biostudies-arrayexpress
TranscriptomicsProfiling of Jurkat T cells activated with CD3, CD28 and PMA and multiple kinase inhibitors
T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into the Th1, Th2, Th17 or iTreg phenotype, depending on environmental co-stimulatory signals. In order to identify the genes and pathways involved in differentiation of Jurkat T cells towards Th1 and Th2 subtypes ...
ORGANISM(S): Homo sapiens 
2011-07-15 | E-GEOD-30674 | biostudies-arrayexpress
ProteomicsTargeted MRM assay Complement System in Health and Infectious Disease
The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. Howev...
ORGANISM(S): Homo Sapiens 
PXD014264 | panorama
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