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TranscriptomicsIdentification of candidate genes regulated by E4bp4 in murine bone marrow
E4bp4 is essential for the development of natural killer (NK) cells. We sought to identify downstream targets of E4bp4 by comparing mRNA expression in wild type vs. E4bp4 knockout Lineage-depleted bone marrow, which is enriched for haematopoietic progenitor cells. We then went on to validate these t...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-55014 | biostudies-arrayexpress
TranscriptomicsIn vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs
Dicer is an RNase III-family endoribonuclease and haploinsufficient tumor suppressor that is required for the biogenesis of miRNAs, yet in vivo structure-function characterization of its RNase IIIA and IIIB domains have not been reported. In murine Dicer knockout fibroblasts, we expressed human Dic...
ORGANISM(S): Mus musculus 
2012-07-13 | E-GEOD-36978 | biostudies-arrayexpress
UnknownMixed methods feasibility study for the surviving opioid overdose with naloxone education and resuscitation (SOONER) trial.
Not available
S-EPMC8244470 | biostudies-literature
TranscriptomicsProliferation and Tumorigenesis of a Murine Sarcoma Cell Line in the Absence of Dicer
MicroRNAs are a class of short ~22 nucleotide RNAs predicted to regulate nearly half of all protein-coding genes, including many involved in basal cellular processes and organismal development. Although both increases and decreases in the levels of specific miRNAs have been shown to promote tumor d...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-34825 | biostudies-arrayexpress
ProteomicsMORC2 phosphorylation fine tunes its DNA compaction activity
Variants in the poorly characterised oncoprotein, MORC2, a chromatin remodelling ATPase, lead to defects in epigenetic regulation and DNA damage response. MORC2 variants are associated with multiple cancers and neurological disorders1,2. The C-terminal domain (CTD) of MORC2 is often phosphorylated i...
ORGANISM(S): Homo sapiens (Human) 
2025-05-05 | PXD053383 | Pride
Hydrogen deuterium exchange mass spectrometry Chromatin remodelling Crosslink mass spectrometry Atpase Epigenetics Single molecule Flim-fret Ffs Cryo-electron microscopy 
UnknownStereotactic ablative radiotherapy for the comprehensive treatment of 1-3 Oligometastatic tumors (SABR-COMET-3): study protocol for a randomized phase III trial.
Not available
S-EPMC7201684 | biostudies-literature
UnknownCommon variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk.
Not available
S-EPMC5053356 | biostudies-literature
UnknownAnimal lifestyle affects acceptable mass limits for attached tags.
Not available
S-EPMC8548787 | biostudies-literature
UnknownGenome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.
Not available
S-EPMC5253627 | biostudies-literature
UnknownImplementation of a best-practice model of care for cognitive impairment and dementia for first nations peoples attending primary care in Australia: a stepped-wedge cluster-randomised trial.
Not available
S-EPMC12002872 | biostudies-literature
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