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TranscriptomicsTimecourse gene expression microarray analysis of bi-allelic targeted Setdb1 mutant mouse ES cells, comparing cells with one inducible conditional (floxed) null allele and a second constitutive null allele, to control mouse ES cell lines.
Gene expression microarray analysis of Setdb1 inducible conditional (floxed) mutant (Setdb1^tm1c(EUCOMM)Wtsi/Setdb1^tm1Wcs) compared to control (Setdb1^tm1c(EUCOMM)Wtsi/+) ES cell lines, without 4'OHT treatment, and timecourse samples following a 48 hour 4'OHT treatment. The 4'OHT induces Cre recom...
ORGANISM(S): Mus musculus 
2017-09-12 | E-MTAB-5931 | biostudies-arrayexpress
ProteomicsRemoving the mutant: Allele-selective knock-out ameliorates VWD type 2 in patient-derived ECFCs
Treatment of von Willebrand disease (VWD) has been topic of discussions and research for several decades. The (genetic) heterogeneity of the inherited bleeding disorder remains one of the biggest obstacles for proper treatment, as well as the high costs of (recombinant) factor concentrates of VWF. I...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD064937 | Pride
Vwd Peptide analysis Endothelial cells Variant detection Allele knockout 
TranscriptomicsLyl-1 knockout vs wildtype Lymphoid Primed Multipotent Progenitors (LMPPs)
We compared gene expression differences in Lyl-1 knockout vs wildtype LMPPs KO allele described in Pub Med ID: 21387538 LMPPS were purified as Lineage-negative, Sca-1+ c-Kit+ (LSK) and Flt3-high from both Lyl1-null and WT mice on C57Bl/6 background
ORGANISM(S): Mus musculus 
2012-06-13 | E-GEOD-38681 | biostudies-arrayexpress
TranscriptomicsBrain BRCA1 conditional knockout
BRCA1 nestin CRE conditional knockout cortrices of P7 animals were compared to wildtype littermates to characterize the mutant phenotype. Keywords: expression BRCA1 conditional knockouts using nestin CRE and a null allele with an inverted neo cassette at the 5' end of the exon 11 of BRCA1 on one fl...
ORGANISM(S): Mus musculus 
2011-09-07 | E-GEOD-6310 | biostudies-arrayexpress
UnknownMutant allele knockout with novel CRISPR nuclease promotes myelopoiesis in ELANE neutropenia.
Not available
S-EPMC9240714 | biostudies-literature
UnknownGeneration and identification of a conditional knockout allele for the PSMD11 gene in mice.
Not available
S-EPMC7849139 | biostudies-literature
UnknownAllele-Specific Knockout by CRISPR/Cas to Treat Autosomal Dominant Retinitis Pigmentosa Caused by the G56R Mutation in NR2E3.
Not available
S-EPMC7961898 | biostudies-literature
UnknownPrecise and Rapid Validation of Candidate Gene by Allele Specific Knockout With CRISPR/Cas9 in Wild Mice.
Not available
S-EPMC6390232 | biostudies-literature
TranscriptomicsKnockout mice reveal key roles for claudin-18 in alveolar fluid homeostasis.
Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJ), where they serve as regulators of paracellular permeability to ions and solutes. Claudin-18, a member of the large claudin family, is highly expressed in lung epithelium. To elucidate the role of claudin-18 i...
ORGANISM(S): Mus musculus 
2014-04-06 | E-GEOD-48443 | biostudies-arrayexpress
UnknownGeneration of gene-of-interest double allele knockout clones in primary human T cells by CRISPR.
Not available
S-EPMC10362176 | biostudies-literature
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