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TranscriptomicsMicroarray analysis of WT and Tfap4-KO CD8 T cells during early activation
Gene expression of Tfap4–/– and WT CD8+ T cells were compared after activation with anti-CD3 and anti-CD28 antibodies in vitro or with Listeria monocytogenes infection in vivo For in vitro activation, naive CD8+ T cells were purified from WT and Tfap4–/– mice and activated with anti-CD3 and ...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-58078 | biostudies-arrayexpress
TranscriptomicsRNAi knock-down of VSG in T. brucei for 1 or 3 days
As an additional strategy for investigating T. brucei transcriptome responsiveness, the mRNA of a highly important protein, the variant surface glycoprotein (VSG) the major surface protein in the bloodstream stage, was suppressed with RNAi. VSG RNAi results in arrest of cell cycle progression...
ORGANISM(S): Trypanosoma brucei 
2008-06-26 | E-MEXP-1528 | biostudies-arrayexpress
TranscriptomicsExpression data from INTS8 human mutants and controls
The Integrator Complex (IC) is responsible for the 3'-end processing of the U1/U2 major spliceosome snRNAs. Maturation of these snRNAs is essential for the proper function of the major spliceosome. Also, there is accumulating evidence that the IC is necessary for normal vertebrate development, howev...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-48849 | biostudies-arrayexpress
UnknownProgression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation.
Not available
S-EPMC12767604 | biostudies-literature
TranscriptomicsTranscrition profiling of Langerhans Cell Histiocytosis to determine cell specific gene expression
Langerhans-cell histiocytosis (LCH) is characterized by heterogeneous lesions containing CD207+ Langerhans cells (LCs) and lymphocytes. In this study, we isolated CD207+ cells and CD3+ T cells from LCH lesions to determine cell-specific gene expression. Compared to control epidermal CD207+ cells,...
ORGANISM(S): Homo sapiens 
2010-03-23 | E-GEOD-16395 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human colorectal cancer epithelial (HCT116) p53 null cells treated with SN38 for 6, 12 and 24h
HCT116 p53 null cells were treated with 5nM SN38 (active metabolite of CPT-11) for 6, 12 and 24h. Following this RNA was harvested for transcriptional profiling.
ORGANISM(S): Homo sapiens 
2007-11-30 | E-MEXP-1194 | biostudies-arrayexpress
ProteomicsPrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impact
Prion protein (PrP) concentration controls the kinetics of prion replication and is a genetically and pharmacologically validated therapeutic target for prion disease. In order to evaluate PrP concentration as a pharmacodynamic biomarker and assess its contribution to known prion disease risk factor...
ORGANISM(S): Homo Sapiens Rattus Norvegicus 
2022-02-28 | PXD031432 | panorama
TranscriptomicsDual RNA-seq of THP-1 macrophages infected with JE2 WT and ΔessC at 2 and 6 hours post infection
This experiment was conducted to uncover global transcription differences caused by Staphylococcal T7SS during early and mid-late macrophage infection.
ORGANISM(S): mixed sample 
2026-01-01 | E-MTAB-16250 | biostudies-arrayexpress
UnknownThe CNS relapse in T-cell lymphoma index predicts CNS relapse in patients with T- and NK-cell lymphomas.
Not available
S-EPMC11261035 | biostudies-literature
UnknownHormone receptor activities of complex mixtures of known and suspect chemicals in personal silicone wristband samplers worn in office buildings.
Not available
S-EPMC9937064 | biostudies-literature
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