Sort   by:  
 Page size 
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
MetabolomicsCD5L inhibits allergic airway inflammation by lysophosphatidylcholine-induced ILC2 apoptosis

Group 2 innate lymphoid cells (ILC2s) play key roles in allergic asthma development. We have previously revealed the inhibitory effect of CD5 antigen-like protein (CD5L) on allergic airway inflammation. Here, we analyzed the effect of CD5L on ILC2s.

2025-09-04 | MTBLS12937 | MetaboLights
MetabolomicsLysosomal Acidity and Cathepsin L Activate Eosinophils via ARG1-Mediated Arginine Metabolism in Allergic Airway Inflammation

Eosinophils are the predominant immune cells implicated in the pathogenesis of asthma, highlighting the need for strategies to mitigate their effects. While previous studies have indicated a potential relationship between lysosomes and eosinophils, the precise role of lysosomes in eosinophil acti...

2025-09-15 | MTBLS13001 | MetaboLights
MetabolomicsUnderstanding systemic and local inflammation induced by nasal polyposis: role of the allergic phenotype (part-I)
Not available
ORGANISM(S): Homo sapiens 
ST001733 | MetabolomicsWorkbench
MetabolomicsUnderstanding systemic and local inflammation induced by nasal polyposis: role of the allergic phenotype (part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001734 | MetabolomicsWorkbench
MetabolomicsmTOR regulates metabolic adaptation of APCs in the lung microenvironment and controls the outcome of allergic inflammation
Not available
ORGANISM(S): Mus musculus 
ST000657 | MetabolomicsWorkbench
TranscriptomicsPooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma
We performed a pooled GWAS and individual genotyping in 269 children with allergic respiratory diseases comparing allergic children with and without asthma. We used a modular approach to identify the most significant loci associated with asthma by combining silhouette statistics and physical distanc...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-24481 | biostudies-arrayexpress
TranscriptomicsTo Study the effects of antioxidant on allergic airways inflammations
Ragweed challenge in Ragweed (RWE) sensitized animals generates Reactive oxygen species (ROS) in the airway epithelium and induces allergic airway inflammation. We want to study the genes induced by ROS generated by RWE. This goal can be achieved by comparing PBS challenge vs. RWE challenge. Keywor...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-18083 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Cannabinoid receptor double knockouts (Cnr1 -/- /Cnr2 -/-) in CHS model to investigate cutaneous contact hypersensitivity
We evaluated cutaneous contact hypersensitivity (CHS) in Cnr1-/-/Cnr2-/- animals using the obligate contact allergen 2,4-dinitrofluorobenzene (DNFB), which generates a specific cutaneous T-cell mediated allergic response upon repeated allergen contact. Allergic contact dermatitis affects about 5% of...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-7694 | biostudies-arrayexpress
MetabolomicsPlasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy.

OBJECTIVE: Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs, and an established natural animal model for human epilepsy types with genetic and unknown etiology. However, the metabolic pathways underlying IE remain largely unknown. METHODS: Plasma samples of healthy...

2025-07-02 | MTBLS10915 | MetaboLights
Sort   by:  
 Page size