Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma

ABSTRACT: We performed a pooled GWAS and individual genotyping in 269 children with allergic respiratory diseases comparing allergic children with and without asthma. We used a modular approach to identify the most significant loci associated with asthma by combining silhouette statistics and physical distance method with cluster-adapted thresholding. We found 97% concordance between pooled GWAS and individual genotyping, with 36 out of 37 top-scoring SNPs significant at individual genotyping level. The most significant SNP is located inside the coding sequence of C5, an already identified asthma susceptibility gene, while the other loci regulate functions that are relevant to bronchial physiopathology, as immune- or inflammation-mediated mechanisms and airway smooth muscle contraction. Integration

ORGANISM(S): Homo sapiens

SUBMITTER: Giampaolo Ricci 

PROVIDER: E-GEOD-24481 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress