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We used spontaneously hypertensive rats (SHRs) as an animal model of hypertensive heart disease and treated them with allisartan orally. We continuously monitored the rats' blood pressure levels, measured their body and heart weights, and evaluated their cardiac structure and function using echocard...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-02-27 | PXD048882 | Pride
Transcriptome and Proteome Analysis Reveals Upregulation of GSTM2 by Allisartan Improving Cardiac Remodeling and Dysfunction in Hypertensive Rat
Abstract Background: Long-term hypertension can lead to hypertensive heart disease, which ultimately progresses to heart failure. As an angiotensin receptor blocker (ARB) antihypertensive drug, allisartan can control blood pressure and improve cardiac remodeling and cardiac dysfunction caused by hyp...
ORGANISM(S): Rattus norvegicus 
2024-02-27 | GSE254800 | GEO
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