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TranscriptomicsTranscription profiling of skeletal muscle from diabetic or non-diabetic Mexican Americans with or without a family history of diabetes
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulati...
ORGANISM(S): Homo sapiens 
2007-06-28 | E-CBIL-28 | biostudies-arrayexpress
ProteomicsSkeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease
Skeletal muscle has recently arisen as a novel regulator of Central Nervous System (CNS) function and aging, secreting bioactive molecules known as myokines with metabolism-modifying functions in targeted tissues, including the CNS. Here we report the generation of a novel transgenic mouse with enha...
ORGANISM(S): Mus Musculus 
2023-12-06 | PXD045241 | panorama
UnknownPhase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105.
Not available
S-EPMC4451172 | biostudies-literature
TranscriptomicsMicroarray analysis of surgical liver biopsies from 13 obese (nine with type 2 diabetes) and five control subjects
Hepatic lipid accumulation is an important complication of obesity linked to risk for type 2 diabetes. To identify novel transcriptional changes in human liver which could contribute to hepatic lipid accumulation and associated insulin resistance and type 2 diabetes (DM2), we evaluated gene expressi...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-15653 | biostudies-arrayexpress
TranscriptomicsNovel Immunotherapy-Induced Tertiary Lymphoid Aggregates Accumulate as Intratumoral Nodal Structures of Immune Regulation in Pancreatic Cancer
Immunotherapy provides an alternative approach for cancer treatment. However, in-depth analyses of the effects of immunotherapy on the tumor microenvironment (TME) have not been conducted in non-melanoma tumors. Here we describe changes in the pancreatic ductal adenocarcinoma (PDAC) TME following i...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-52171 | biostudies-arrayexpress
TranscriptomicsOpposing Roles of STAT1 and STAT3 in IL-21 Function in CD4+ T cells
Interleukin-21 (IL-21) is a type 1 cytokine essential for immune cell differentiation and function. Although IL-21 can activate several STAT family transcription factors, previous studies focused mainly on the role of STAT3 in IL-21 signaling. Here, we investigated the role of STAT1 and show that ST...
ORGANISM(S): Mus musculus 
2015-07-01 | E-GEOD-63204 | biostudies-arrayexpress
UnknownThe Liver Retransplantation Risk Score: a prognostic model for survival after adult liver retransplantation.
Not available
S-EPMC8518385 | biostudies-literature
TranscriptomicsHuman skeletal muscle - type 2 diabetes and family history positive individuals - Mexican American
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulati...
ORGANISM(S): Homo sapiens 
2010-04-27 | E-GEOD-21340 | biostudies-arrayexpress
UnknownElective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
Not available
S-EPMC8189635 | biostudies-literature
UnknownLandscape of human antibody recognition of the SARS-CoV-2 receptor binding domain.
Not available
S-EPMC8463300 | biostudies-literature
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