Transcription profiling of skeletal muscle from diabetic or non-diabetic Mexican Americans with or without a family history of diabetes

ABSTRACT: Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with insulin resistance, but no specific defect responsible for insulin resistance and DM has been identified in humans. To identify genes potentially important in the pathogenesis of DM, we analyzed gene expression in skeletal muscle from healthy metabolically characterized nondiabetic (family history negative and positive for DM) and diabetic Mexican-American subjects. We demonstrate that insulin resistance and DM associate with reduced

INSTRUMENT(S): Affymetrix Fluidics Station 400

ORGANISM(S): Homo sapiens

DISEASE(S): diabetes mellitus type 2

SUBMITTER: Mary-Elizabeth Patti 

PROVIDER: E-CBIL-28 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress