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ProteomicsAllotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV‐2 S1 Spike Glycoprotein
Cytotoxic T-lymphocytes are critical determinants of SARS-CoV-2 infection severity and long-term immunity. A hallmark of COVID-19 is its highly variable severity and breadth of immune responses between individuals. To address the underlying mechanisms behind this phenomenon we analyzed the proteolyt...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 
2021-11-25 | PXD027006 | Pride
Peptidomics Allotypic variation Sars-cov‐2 s1 spike glycoprotein Erap1 
UnknownEffect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design.
Not available
S-EPMC7990158 | biostudies-literature
ProteomicsERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytes
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a polymorphic enzyme that shapes the peptide repertoire presented by MHC class I molecules and can regulate adaptive immune responses in cancer and autoimmunity. Common missense polymorphisms in ERAP1 modulate its activity and are found in specific a...
ORGANISM(S): Homo sapiens (Human) 
2025-11-04 | PXD066752 | Pride
Erap1 Allotypes Immunopeptidomics 
UnknownAllotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein.
Not available
S-EPMC8530767 | biostudies-literature
UnknownA comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors.
Not available
S-EPMC4966604 | biostudies-literature
UnknownImpact of structural modifications of IgG antibodies on effector functions.
Not available
S-EPMC10800522 | biostudies-literature
UnknownERAP1 Allotypes 2 and 10 Differentially Regulate the Immunopeptidome of Melanocytes.
Not available
S-EPMC12779449 | biostudies-literature
UnknownFcγR Binding and ADCC Activity of Human IgG Allotypes.
Not available
S-EPMC7218058 | biostudies-literature
UnknownDynamics of inter-heavy chain interactions in human immunoglobulin G (IgG) subclasses studied by kinetic Fab arm exchange.
Not available
S-EPMC3937676 | biostudies-literature
UnknownCommon allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties.
Not available
S-EPMC8024916 | biostudies-literature
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