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ProteomicsERAP1 as a regulator of the immunopeptidome, proteome and cellular homeostasis of cancer cells. Immunopeptdome_PartII
Endoplasmic reticulum aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes the peptide repertoire available for binding to Major Histocompatibility Class I molecules (MHC-I). Moreover, it may have additional effects on cellular homeostasis, which have not been explored. To address ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-23 | PXD054494 | Pride
Cancer Erap1 Antigen presentation Proteomics Mhc-i Immunopeptidomics Antigen trimming 
ProteomicsThe inhibition effect of ERAP1-IN-1 on HepG2.2.15 cells
In our strudy, we preterated HepG2.2.15 cells with specific ERAP1 inhibitor ERAP1-IN-1(50μM). And then LC-MS/MS analysis was performed on a timsTOF Pro mass spectrometer.Finally we found that among the total peptides identified, ERAP1-IN-1-treated group had an reduction of the numbers of long pepti...
ORGANISM(S): Homo Sapiens 
2022-02-24 | PXD031858 |
GenomicsERAP1 deficiency exacerbates DSS-induced colitis and alters sulfasalazine efficacy via immune dysregulation
ERAP1 deficiency exacerbates DSS-induced colitis and alters sulfasalazine efficacy via immune dysregulation
PRJNA1275756 | ENA
ProteomicsERAP1 as a regulator of the immunopeptidome, proteome and cellular homeostasis of cancer cells. A375 Immunopeptidome, Part I.
Endoplasmic reticulum aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes the peptide repertoire available for binding to Major Histocompatibility Class I molecules (MHC-I). Moreover, it may have additional effects on cellular homeostasis, which have not been explored. To address ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-23 | PXD054491 | Pride
Cancer Erap1 Antigen presentation Proteomics Mhc-i Immunopeptidomics Antigen trimming 
TranscriptomicsERAP1 deficiency exacerbates DSS-induced colitis and alters sulfasalazine efficacy via immune dysregulation
UIntroduction: Ulcerative colitis (UC) is a life-threatening heterogeneous condition characterized by inflammation of the colon. Endoplasmic reticulum aminopeptidase 1 (ERAP1) is essential for antigen processing and immune regulation, however, its specific role in UC pathogenesis and therapeutic res...
ORGANISM(S): Mus musculus 
2025-06-17 | GSE299626 | GEO
ProteomicsERAP1 activity modulates the immunopeptidome but also affects the proteome, metabolism and stress responses in cancer cells
Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes the peptide repertoire available for binding to Major Histocompatibility Complex Class I molecules (MHC-I). Moreover, it may have additional effects on cellular homeostasis, which have not been explored...
ORGANISM(S): Homo sapiens (Human) 
2025-05-23 | PXD060572 | Pride
Cancer Proteomics Erap1 A375 cells 
ProteomicsERAP1 activity modulates the immunopeptidome but also affects the proteome, metabolism and stress responses in cancer cells
Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) metabolizes peptides inside the ER and shapes the peptide repertoire available for binding to Major Histocompatibility Complex Class I molecules (MHC-I). Moreover, it may have additional effects on cellular homeostasis, which have not been explored...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD060575 | Pride
Cancer Proteomics Erap1 Thp1 cells 
ProteomicsIDENTIFICATION OF AN UNCONVENTIONAL SUBPEPTIDOME BOUND TO THE BEHÇET’S DISEASE - ASSOCIATED HLA–B*51:01 THAT IS REGULATED BY ENDOPLASMIC RETICULUM AMINOPEPTIDASE 1 (ERAP1)
Human leukocyte antigen (HLA) - B*51:01 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are two strong predisposing genetic factors to Behçet's disease (BD). Previous studies have focused on two subgroups of HLA-B*51 peptidome containing Proline (Pro) or Alanine (Ala) at position 2 (P2). Little i...
ORGANISM(S): Homo sapiens (Human) 
2020-03-18 | PXD013064 | Pride
Erap1  hla–b*51:01  behçet’s disease 
ProteomicsERAP1 allotypes 2 and 10 differentially regulate the immunopeptidome of melanocytes
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a polymorphic enzyme that shapes the peptide repertoire presented by MHC class I molecules and can regulate adaptive immune responses in cancer and autoimmunity. Common missense polymorphisms in ERAP1 modulate its activity and are found in specific a...
ORGANISM(S): Homo sapiens (Human) 
2025-11-04 | PXD066752 | Pride
Erap1 Allotypes Immunopeptidomics 
ProteomicsThe Behçet’s Disease associated Hap10 variant of ERAP1 generates a low affinity HLA-B*51 peptidome through differential processing of two subpeptidomes
HLA-B*51, the main risk factor for Behçet’s disease (BD), binds two main subpeptidomes consisting of low affinity peptides with Ala as their second amino acid and higher affinity peptides with Pro at this position. A low activity variant of ERAP1, Hap10, is uniquely associated with BD susceptibility...
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006215 | Pride
Behçet's disease Erap1 Hla-b*51 Antigen processing 
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