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TranscriptomicsNovel Properties of Side Population cells in Soft-tissue Sarcoma, and How They May Be Targeted to Develop Potential Therapies
Tumours contain heterogeneous cell populations. A population enriched in tumour-initiating potential has been identified in soft-tissue sarcoma (STS) by the isolation of side population (SP) cells. In this study, we compared the gene expression profiles of SP and non-SP cells in STS and identified H...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-24199 | biostudies-arrayexpress
UnknownPrimary care virtual resource use prior and post COVID-19 pandemic onset.
Not available
S-EPMC9673210 | biostudies-literature
Unknownβ-Catenin-regulated myeloid cell adhesion and migration determine wound healing.
Not available
S-EPMC4089463 | biostudies-literature
UnknownPrestress in the extracellular matrix sensitizes latent TGF-β1 for activation.
Not available
S-EPMC4210443 | biostudies-literature
UnknownPharmacologic targeting of β-catenin improves fracture healing in old mice.
Not available
S-EPMC6588693 | biostudies-literature
TranscriptomicsProfiling Side Population Cells in Malignant Fibrous Histiocytoma
We are currently studying the mechanisms that confer tumour initiating potential upon SP, and as part of this work, we undertook gene profiling studies comparing expression between SP and non-SP cells, initially focusing on the most common soft tissue sarcoma, malignant fibrous histiocytoma (or MFH)...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-32375 | biostudies-arrayexpress
TranscriptomicsHedgehog pathway inhibition in chondrosarcoma using the Smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth
Mice bearing primary human chondrosarcoma xenografts were treated with IPI 926, and mRNA levels of known Hh pathway genes and endpoint tumor volumes were measured. Gene expression profiling of IPI-926 treated tumors was conducted to identify potential novel Hh target genes. 4 Control treated and 4 I...
ORGANISM(S): Homo sapiens 
2014-03-18 | E-GEOD-44581 | biostudies-arrayexpress
UnknownMechanism of hard-nanomaterial clearance by the liver.
Not available
S-EPMC5132626 | biostudies-literature
UnknownEfficacy of auranofin as an inhibitor of desmoid progression.
Not available
S-EPMC9279441 | biostudies-literature
UnknownMacrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.
Not available
S-EPMC6281653 | biostudies-literature
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