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ProteomicsChronic pain susceptibility is associated with anhedonic behavior and alterations in the accumbal ubiquitin-proteasome system
It remains unknown why upon similar acute/subacute painful conditions, pain persists in some individuals while in others it resolves. Genetic factors, mood, and functional alterations, particularly involving the mesolimbic network, appear to be key. In order to explore potential susceptibility/resis...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-04-27 | PXD022478 | Pride
Neuropathic pain  allodynia  proteomic screening  nucleus accumbens  resistance  proteasome 
TranscriptomicsRNA-seq of blood samples from patients diagnosed with visceral leishmaniasis and asymptomatic individuals (Brazil)
To ascertain which genes are involved in the outcome of Leishmania infantum infection and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients diagnosed with active VL compared to asymptomatic individuals (positive ser...
ORGANISM(S): Homo sapiens 
2020-08-06 | E-MTAB-8818 | biostudies-arrayexpress
ProteomicsNew insights on sperm function in male infertility of unknown origin: proteomics characterization
The global trend on (male)infertility is concerning and the unidentifiable causes in half of the cases demands a better understanding of the molecular, biochemical and metabolic mechanisms as well as the identification of external and internal factors operating behind it, that might help to explain ...
ORGANISM(S): Homo sapiens (Human) 
2024-02-28 | PXD040292 | Pride
Xxxxxxidiopathic male infertility  unexplained male infertility  sperm function  sperm proteomics 
TranscriptomicsBulk mRNA-seq of blood samples of visceral leishmaniasis patients during active disease and after treatment (cured), asymptomatic individuals and healthy uninfected control volunteers.
To ascertain which genes are involved in the outcome of Leishmania infantum infections and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients during active VL compared to the same patients 180 days after being treate...
ORGANISM(S): Homo sapiens 
2022-03-10 | E-MTAB-11047 | biostudies-arrayexpress
ProteomicsInfluence of substrate stiffness on the proteome of undifferentiated human umbilical cord matrix mesenchymal stem/stromal cells (hUCM-MSCs)
Cells sense the biophysical properties of the surrounding microenvironment. In particular, the stiffness of the extracellular milieu can be interrogated by cells and integrated through mechanotransduction. Many cellular processes (like proliferation, migration, or differentiation) depend on the mech...
ORGANISM(S): Homo sapiens (Human) 
2020-07-20 | PXD017674 | Pride
Mechanotransduction  cytoskeleton  mscs  proteomics  swath-ms 
UnknownDistinct mesenchymal cell states mediate prostate cancer progression.
Not available
S-EPMC10774315 | biostudies-literature
TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
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