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GenomicsFactors influencing in vivo deposition of histone variants H3.1 and H3.3
Establishment of a proper chromatin landscape is central to genome function. Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRA histone chaperones. Impairing replicative H3.1 incorporation via CAF-1 enables an alternative H3.3 depos...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-31794 | biostudies-arrayexpress
GenomicsGenome-wide maps of WT and over-expressing CenH3/CENP-A in Human HeLa S3 cells
Centromeres are essential to ensure proper chromosome segregation in eukaryotes. Their definition relies on the presence of a centromere-specific H3 histone variant CenH3, known as CENP-A in mammals. Its overexpression in aggressive cancers raises questions concerning its effect on chromatin dynamic...
ORGANISM(S): Homo sapiens 
2014-02-12 | E-GEOD-42951 | biostudies-arrayexpress
GenomicsDistribution of total histone variants H3.1 and H3.3 in pluripotent mouse embryonic stem cells (mESCs) and in vitro differentiated neuronal precursor cells (NPCs)
We profiled the enrichment of the replicative H3.1 and non-replicative H3.3 histone variants using the SNAP-seq assay previously developed in the team (Gatto et al., 2022, Forest et al., 2023). We used KH2 mouse embryonic stem cells (mESCs) bearing doxycycline-inducible H3.1/H3.3-SNAP, which were ex...
ORGANISM(S): Mus musculus 
2025-04-24 | E-MTAB-14240 | biostudies-arrayexpress
UnknownWhole genome duplication through mitotic slippage causes nuclear instability
Not available
S-SCDT-10_1038-S44318-026-00912-Y | biostudies-other
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