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ProteomicsAlovudine Targets mtDNA‑Dependent Proteins Encoded by Genes Recurrently Amplified in Metastatic Breast Cancer Cohorts
Previously, we demonstrated that high levels of mtDNA were functionally associated with “stemness” and aggressive phenotypic behaviours in human breast cancer cells, including spontaneous metastasis. More specifically, we showed that treatment with Alovudine induced mtDNA-depletion in MDA-MB-231 cel...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD077655 | Pride
Mtdna Mtdna-depletedrho(0) cells Mitochondria Alovudine Breast cancer Proteomics Metastasis 
UnknownThe flap endonuclease-1 promotes cellular tolerance to a chain-terminating nucleoside analog, alovudine, by counteracting the toxic effect of 53BP1.
Not available
S-EPMC12270548 | biostudies-literature
UnknownHigh mitochondrial DNA content is a key determinant of stemness, proliferation, cell migration, and cancer metastasis in vivo.
Not available
S-EPMC11470112 | biostudies-literature
UnknownSynthesis and Biological Evaluation of 5'-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors.
Not available
S-EPMC4001930 | biostudies-literature
UnknownNucleotide analogues as inhibitors of SARS-CoV Polymerase.
Not available
S-EPMC7596664 | biostudies-literature
UnknownThe Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)'s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19.
Not available
S-EPMC10057333 | biostudies-literature
UnknownA library of nucleotide analogues terminate RNA synthesis catalyzed by polymerases of coronaviruses that cause SARS and COVID-19.
Not available
S-EPMC7299870 | biostudies-literature
MetabolomicsPrevotella vs. Ruminococcus enterotypes drive divergent milk fat synthesis in dairy cows through rumen microbiota-host metabolic crosstalk

Background: High-yield dairy cows are usually accompanied with lower milk fat (MF) rate, with huge variations in MF contents among individuals. The potential mechanisms of key microorganisms, their genes and metabolites participate in MF synthesis are still not well understood. By selec...

2025-10-28 | MTBLS13211 | MetaboLights
MetabolomicsMicrobial Diversity and Non-volatile Metabolites Profile of Low-Temperature Sausage Stored at Room Temperature
Sausage is a highly perishable food with unique spoilage characteristics primarily because of its specific means of production. The quality of sausage during storage is determined by its microbial and metabolite changes. This study developed a preservative-free low-temperature sausage model and coat...
2021-09-28 | MTBLS2871 | MetaboLights
MetabolomicsMetabolic disorder and intestinal microflora dysbiosis in chronic inflammatory demyelinating polyradiculoneuropathy

OBJECTIVE: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare acquired immune-mediated neuropathy. Although microbial infection is potentially a contributing factor, a causative link between CIDP and microbial infection remains unclear. There is also no de...

2023-01-16 | MTBLS5828 | MetaboLights
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