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TranscriptomicsGene expression profiles of LPS-stimulated RAW264.7 macrophages overexpressing Tbc1d23 novel innate immune gene
We previously identified Tbc1d23 as a candidate novel regulator of innate immunity using comparative genomics RNAi screens in C. elegans and mouse macrophages. Using mice with an engineered knockout mutation in Tbc1d23 and macrophages engineered to overexpress Tbc1d23, we now show that Tbc1d23 is a ...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-30840 | biostudies-arrayexpress
TranscriptomicsEffect of SF3A1 inhibition on pre-mRNA splicing
We previously found that the SF3A mRNA splicing complex was required for a robust innate immune response; SF3A acts in part by inhibiting the production of a negatively acting splice form of the TLR signaling adaptor MyD88. Here we inhibit SF3A1 using RNAi and subsequently perform an RNAseq study to...
ORGANISM(S): Mus musculus 
2015-02-09 | E-GEOD-58432 | biostudies-arrayexpress
UnknownRare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.
Not available
S-EPMC3287292 | biostudies-literature
UnknownFine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Not available
S-EPMC4380767 | biostudies-literature
UnknownEfficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
Not available
S-EPMC5731244 | biostudies-literature
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