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ProteomicsIdentification of alpha-satellite RNA interacting proteins
We set out to identify proteins that bind alpha-satellite ncRNAs in HCT-116 and SW-480 colorectal cancer human cell lines. We performed RNA pulldown followed by mass spectrometry identification of the associated proteins. Among the identified proteins, we observed a statistical overrepresenttion of ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD024582 | Pride
Rna pulldown Ncrna Alpha satellite 
GenomicsSequences Associated with Centromere Competency in the Human Genome
Centromeres, the sites of spindle attachment during mitosis and meiosis, are located in specific positions in the human genome, normally coincident with diverse subsets of alpha satellite DNA. While there is strong evidence supporting the association of some subfamilies of alpha satellite with centr...
ORGANISM(S): Homo sapiens 
2013-03-29 | E-GEOD-45497 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse satellite cells isolated from skeletal muscle
(Abstract of publication submitted currently) To clarify molecular regulation of satellite cells, we performed genome-wide gene expression analysis of quiescent satellite cells isolated from mouse skeletal muscle by flow cytometry. We identified 53 novel quiescent satellite cell-specific genes whos...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3483 | biostudies-arrayexpress
TranscriptomicsGene profiling of quiescent and activated skeletal muscle satellite cells by an in vivo approach
The satellite cell of skeletal muscle provides a paradigm for quiescent and activated tissue stem cell states. We have carried out transcriptome analyses by comparing satellite cells from adult skeletal muscles, where they are mainly quiescent, with cells from growing muscles, regenerating (mdx) mus...
ORGANISM(S): Mus musculus 
2010-01-04 | E-GEOD-15155 | biostudies-arrayexpress
TranscriptomicsRNA-seq from myogenic satellite cells from a translational porcine model for Duchenne muscular dystrophy, heterozygous female carriers, and their healthy wild-type counterpart
Satellite cells (SCs), the stem cell population of skeletal muscle, are crucial for growth and regeneration, and their dysfunction is increasingly recognized as a contributing factor to Duchenne muscular dystrophy (DMD). DMD is a severe, X-linked disorder caused by DMD gene mutations, leading to lo...
ORGANISM(S): Sus scrofa 
2025-12-11 | E-MTAB-16179 | biostudies-arrayexpress
TranscriptomicsRNA-Sequencing of primary myoblasts from mice with a satellite cell specific knockout of the histone demthylase UTX/KDM6A
The KDM6 histone demethylases (UTX/KDM6A and JMJD3/KDM6B) mediate removal of repressive histone H3K27me3 marks to establish transcriptionally permissive chromatin. Loss of UTX in female mice is embryonic lethal. Unexpectedly, male UTX-null mice escape embryonic lethality due to expression of UTY, a ...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-69968 | biostudies-arrayexpress
TranscriptomicsExpression data from differentiating primary culture of equine satellite cells (ESC) incubated with gamma-oryzanol (GO)
Transcriptional profiling of gamma-oryzanol-treated (24h) differentiating equine satellite cells (3rd day of differentiation) compared to control GO-untreated cells. Goal was to determine the effects of gamma-oryzanol influence on gene expression in equine satellite cells during in vitro myogenesis ...
ORGANISM(S): Equus caballus 
2016-02-22 | E-GEOD-73730 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of turkey muscle satellite cells transfected with DAP-siRNA during proliferation and differentiation
In this study, we directly compared turkey muscle satellite cell gene expression between satellite cells with the gene Death-Associated Protein (DAP) knocked down by siRNA transfection and those transfected with a lipofectamine control using our 6K Turkey Skeletal Muscle Long Oligo (TSKMLO) microarr...
ORGANISM(S): Meleagris gallopavo 
2012-05-31 | E-GEOD-35660 | biostudies-arrayexpress
TranscriptomicsNotch signaling/MyoD double deficient embryonic muscle progenitors
Skeletal muscle growth and regeneration rely on myogenic progenitor and satellite cells, the stem cells of postnatal muscle. Elimination of Notch signals during mouse development results in premature differentiation of myogenic progenitors and formation of very small muscle groups. Here we show that...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-39379 | biostudies-arrayexpress
GenomicsA unique chromatin complex occupies young alpha-satellite arrays of human centromeres
Using high-resolution chromatin immunoprecipitation (ChIP) of centromere components and clustering of sequence data we find that specific dimeric alpha-satellite units shared by multiple individuals dominate functional human centromeres. We have analyzed the chromatin landscape of the human genome u...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-60951 | biostudies-arrayexpress
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