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Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_lipid

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12741 | MetaboLights
MetabolomicsRedirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neural activity to establish transcriptional plast...

2021-06-24 | MTBLS2852 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_targeted metabolites

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-16 | MTBLS12731 | MetaboLights
Metabolomicsα-ketoglutarate maintains AMPK translation for energy sensing in human cancer cells_untargeted metabolites_flux_FAO

The energy sensor AMPK promotes tumor cell survival under stress, but how to prevent AMPK activation to blunt tumor progression remains unclear. Here we show that the metabolite α-ketoglutarate (α-KG) controls AMPK translation through a TET-YBX1 axis, which can be exploited to sensitize human can...

2025-07-17 | MTBLS12738 | MetaboLights
MetabolomicsSIRT3-dependent glutaminolysis enhances germinal center epigenetic programming through α-ketoglutarate

Germinal center (GC) B cells depend on sustained epigenetic modulation to maintain transcriptional identity and support affinity maturation; however, whether mitochondrial metabolism directly enhances this chromatin state remains unclear. Here, we show that enhanced SIRT3 activity promotes glutam...

2026-09-04 | MTBLS15385 | MetaboLights
MetabolomicsTargeted degradation of the α-ketoglutarate dehydrogenase mediated by a mitochondrial DNAJC protein regulates metabolism

Mitochondrial heat shock proteins and co-chaperones play essential roles in maintaining proteostasis. They are renowned for regulating unfolded proteins, usually without specific target preferences. In this study, we identified T cell activation inhibitor, mitochondria (TCAIM), as a novel DNAJC-t...

2024-12-03 | MTBLS10440 | MetaboLights
MetabolomicsSpontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters
Not available
ORGANISM(S): Homo sapiens 
ST001860 | MetabolomicsWorkbench
MetabolomicsLC-MS/MS Quantification of Nuclear α-KG in NSCLC
This study contains targeted LC-MS/MS quantification of α-ketoglutarate (α-KG) in NSCLC cells using 13C-labeled α-KG internal standard. Nuclear α-KG levels were measured in A549, A549/DTX, PC9, and PC9/OR cells. In addition, nuclear α-KG was quantified in GLUD1-overexpressing A549 cells and GLUD1-kn...
2026-07-21 | MTBLS15115 | MetaboLights
MetabolomicsReplication study: The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
Not available
ORGANISM(S): Homo sapiens 
ST000548 | MetabolomicsWorkbench
MetabolomicsTCA cycle metabolomics of H3K27M cells grown in regular glutamine media, glutamine free media, and glutamine free media with alpha-ketoglutarate (Part-II)
Not available
ORGANISM(S): Homo sapiens 
ST001024 | MetabolomicsWorkbench
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