Sort   by:  
 Page size 
TranscriptomicsWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Alpk1-deficient mice demonstrate exacerbated colitis and increased IL-12/Th1 response upon challenge with an intestinal pathobiont, Helicobacter hepaticus (Hh). Hematopoietic compartment is driving the pathogenic phenotype in this animal model, and Alpk1 is highly expressed in myeloid cells (macrop...
ORGANISM(S): Mus musculus 
2018-07-30 | E-MTAB-7076 | biostudies-arrayexpress
GenomicsTranscriptomic analysis of ALPK1-dependent responses in BMDMs from WT and ALPK1 knockout C57BL/6 mice upon ADP-Hep stimulation
Transcriptomic analysis of ALPK1-dependent responses in BMDMs from WT and ALPK1 knockout C57BL/6 mice upon ADP-Hep stimulation
PRJNA1330749 | ENA
GenomicsWhole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
Whole transcriptome profiling of the steady state and Hh-treated (8 hrs) Alpk1+/- (heterozygous) and Alpk1-/- (knockout) BMDMs using RNA-Sequencing approach
PRJEB27929 | ENA
TranscriptomicsERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
Cancers are heterogeneous by nature. While traditional oncology screens commonly use a single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal alternative targets that regulate cellular growth by processes other than apoptosis or cell division. We evaluated the...
ORGANISM(S): Homo sapiens 
2016-10-27 | E-GEOD-79630 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of ALPK1-dependent responses in BMDMs from WT and ALPK1 knockout C57BL/6 mice upon ADP-Hep stimulation
The ALPK1 pathway is a cytosolic sensor for the bacterial metabolite ADP-heptose (ADP-Hep), triggering innate immune signalling. To investigate ALPK1-dependent transcriptional responses, bone marrow-derived macrophages (BMDMs) were generated from wild-type (WT) and Alpk1 knockout C57BL/6 mice using ...
ORGANISM(S): Mus musculus 
2025-10-10 | GSE308482 | GEO
UnknownIn vitro kinase assay reveals ADP-heptose-dependent ALPK1 autophosphorylation and altered kinase activity of disease-associated ALPK1 mutants.
Not available
S-EPMC10113258 | biostudies-literature
GenomicsMicrobial metabolite drives ageing-related clonal haematopoiesis via ALPK1 [RNA-seq]
Microbial metabolite drives ageing-related clonal haematopoiesis via ALPK1 [RNA-seq]
PRJNA973978 | ENA
UnknownDown-regulated and Commonly mutated ALPK1 in Lung and Colorectal Cancers.
Not available
S-EPMC4901299 | biostudies-literature
UnknownIFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes.
Not available
S-EPMC11758396 | biostudies-literature
UnknownALPK1 phosphorylates myosin IIA modulating TNF-α trafficking in gout flares.
Not available
S-EPMC4864424 | biostudies-literature
Sort   by:  
 Page size