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ProteomicsAlt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
While thousands of previously unannotated small and alternative open reading frames (alt-ORFs) have recently been revealed in the human genome, the functions of only a handful are currently known, leaving open the question of their biological significance as a class. Using a proteomic strategy for d...
ORGANISM(S): Homo sapiens (Human) 
2020-12-07 | PXD018268 | Pride
Human microprotein alt-protein phosphoproteomics 
UnknownDifferential Evolutionary Selection and Natural Evolvability Observed in ALT Proteins of Human Filarial Parasites.
Not available
S-EPMC4758719 | biostudies-literature
UnknownGut Microbiota Modulates the Protective Role of Ginsenoside Compound K Against Sodium Valproate-Induced Hepatotoxicity in Rat.
Not available
S-EPMC9302921 | biostudies-literature
ProteomicsAntagonistic roles of canonical and alternative-RPA in disease-associated tandem CAG repeat instability
Ongoing CAG expansions in Spinocerebellar ataxia type 1 (SCA1) and Huntington disease (HD) brains exacerbate disease.  Expansions involve aberrant repair of mutagenic slipped-DNAs, formed from single-stranded DNAs.  Whether singlestranded DNA-binding proteins prevent or facilitate expansions is unkn...
ORGANISM(S): Homo sapiens (Human) 
2023-10-13 | PXD044158 | Pride
Cag repeat expansion diseases  spinocerebellar ataxia type 1 (sca1)  huntington's disease (hd)  somatic cag repeat expansions  rpa (single-strand dna binding protein  alternative-rpa (alt-rpa)  dna repair Slipped-dnas  post-mortem brains Sca1 mice 
UnknownA role for monoubiquitinated FANCD2 at telomeres in ALT cells.
Not available
S-EPMC2665210 | biostudies-literature
UnknownA gene expression signature classifying telomerase and ALT immortalization reveals an hTERT regulatory network and suggests a mesenchymal stem cell origin for ALT.
Not available
S-EPMC2875172 | biostudies-literature
UnknownBrugia malayi: comparison of protective immune responses induced by Bm-alt-2 DNA, recombinant Bm-ALT-2 protein and prime-boost vaccine regimens in a jird model.
Not available
S-EPMC2763209 | biostudies-literature
UnknownLongitudinal change in castration-resistant prostate cancer biomarker AST/ALT ratio reflects tumor progression.
Not available
S-EPMC10504303 | biostudies-literature
UnknownAlt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24.
Not available
S-EPMC7820019 | biostudies-literature
UnknownChain end-group selectivity using an organometallic Al(iii)/K(i) ring-opening copolymerization catalyst delivers high molar mass, monodisperse polyesters† † Electronic supplementary information (ESI) available. See https://doi.org/10.1039/d2sc02752f
Not available
S-EPMC9337735 | biostudies-literature
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