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TranscriptomicsSublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human polymorphonuclear leukocyte gene expression and enhance bactericidal capacity.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections are often caused by strains encoding Panton-Valentine leukocidin (PVL). PVL can cause lysis of polymorphonuclear leukocytes (PMNs) and other myeloid cells in vitro, a function considered widely as the primary means...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-33939 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse high and low exploratory genetically identical animals
Genetically identical inbred mice exhibit substantial stable individual variability in exploratory behavior. We used microarrays to look at gene expression differences in the hippocampus in female mice separated by stable differences in exploratory behavior Experiment Overall Design: Balb c/J offsp...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-11680 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Balb c/J offspring subjected to postnatal handling vs. controls
Postnatal handling in rodents leads to decreased anxiety-like behavior in adulthood. We used microarrays to look at gene expression differences in the CA1 region of the hippocampus in female mice subjected to postnatal handling compared to controls. Experiment Overall Design: Balb c/J offspring wer...
ORGANISM(S): Mus musculus 
2008-10-26 | E-GEOD-11679 | biostudies-arrayexpress
TranscriptomicsAutism and increased paternal age related changes in global levels of gene expression regulation
A causal role of mutations in genes encoding for multiple general transcription factors in neurodevelopmental disorders including autism suggested that alterations at the global level of gene expression regulation might also relate to disease risk in sporadic cases of autism. This premise can be tes...
ORGANISM(S): Homo sapiens 
2011-10-08 | E-GEOD-25507 | biostudies-arrayexpress
TranscriptomicsHistone H3 lysine 4 acetylation-methylation dynamics define breast cancer subtypes [RNA-seq]
The onset and progression of breast cancer are linked to genetic and epigenetic changes that alter the normal programming of cells. Epigenetic modifications of DNA and histones contribute to chromatin structure that results in the activation or repression of gene expression. Several epigenetic pathw...
ORGANISM(S): Homo sapiens 
2016-02-10 | E-GEOD-75168 | biostudies-arrayexpress
UnknownPlasma triacylglycerol length and saturation level mark healthy aging groups in humans.
Not available
S-EPMC11979014 | biostudies-literature
GenomicsAn epigenetic memory of pregnancy in the mouse mammary gland
Pregnancy is the major modulator of mammary gland activity. It induces a tremendous expansion of the mammary epithelium and the generation of alveolar structures for milk production. Anecdotal evidence from multiparous humans indicates that the mammary gland may react less strongly to the first preg...
ORGANISM(S): Mus musculus 
2015-05-15 | E-GEOD-67386 | biostudies-arrayexpress
TranscriptomicsA High-Fat Diet and NAD+ Rescue Premature Aging in Cockayne Syndrome
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in the genes encoding the DNA repair proteins CSA or CSB. Csbm/m mice were given a high-fat, caloric-restricted or resveratrol-supplemented diet. The high-fat diet rescued the p...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-62194 | biostudies-arrayexpress
UnknownSplice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.
Not available
S-EPMC8208822 | biostudies-literature
UnknownMicrobial functional changes mark irreversible course of Tibetan grassland degradation.
Not available
S-EPMC9106683 | biostudies-literature
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