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TranscriptomicsHnRNPLL is a global regulator of alternative splicing in activated T cells
HnRNPLL was identified as a critical regulator of CD45 alternative splicing in a lentiviral shRNA screen. RNAi-mediated depletion of hnRNPLL eliminated the activation-induced induced transition from the CD45RA to the CD45RO isoform. HnRNPLL is induced during the process of T cell activation, raising...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-11834 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.
Splicing factor SRSF10 is known to function as a sequence-specific splicing activator. Here, we used RNA-seq coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. We found that SRSF10 promoted both exon inclusion and exclusion. Function...
ORGANISM(S): Gallus gallus 
2014-01-22 | E-GEOD-53354 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Event Amplifies Evolutionary Differences Between Vertebrates
Alternative splicing (AS) generates extensive transcriptomic and proteomic complexity. However, the functions of species- and lineage-specific splice variants are largely unknown. Here, we show that mammalian-specific skipping of exon 9 of PTBP1 alters its splicing regulatory activities and affects ...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-69656 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of alternative splicing regulation by insulin and wingless signalling in Drosophila cells
Background: Despite the prevalence and biological relevance of both signalling pathways and alternative pre-mRNA splicing, our knowledge of how intracellular signalling impacts on alternative splicing regulation remains fragmentary. We report a genome-wide analysis of changes in alternative splicing...
ORGANISM(S): Drosophila melanogaster 
2010-05-06 | E-GEOD-14085 | biostudies-arrayexpress
TranscriptomicsCombinatorial role of two paralogous splicing factors, hnRNP L and L-like, in multiple-exon regulation of CD45 alternative splicing
The goal of this study was to investigate the role of hnRNP L-like in alternative pre-mRNA splicing in human B-cells through an RNA-Seq approach. RNA-Seq was performed in DG75 cell line with over expression of hnRNP L-like or GFP as control.
ORGANISM(S): Homo sapiens 
2012-03-28 | E-GEOD-33013 | biostudies-arrayexpress
TranscriptomicsGene Array Analyzer (GAA): Alternative usage of gene arrays to study alternative splicing events
This SuperSeries is composed of the following subset Series: GSE30429: Gene Array Analyzer (GAA): Alternative usage of gene arrays to study alternative splicing events (MoGene array) GSE32998: Gene Array Analyzer (GAA): Alternative usage of gene arrays to study alternative splicing events (MoEx arra...
ORGANISM(S): Mus musculus 
2011-11-28 | E-GEOD-33183 | biostudies-arrayexpress
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_IL102, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM11210041929 | GPMDB
OtherNovel molecular insights into classical and alternative activation states of microglia as revealed by SILAC-based proteomics.
Data from ProteomeXchange, 888 Proteomic analysis of microglial activation states, 1676 Microglial activation characterization. Experiment: BV2_LPS_1, file: folder summary. Published as part of Mol Cell Proteomics. 2015 Sep 30 . From the Abstract: {{i}} Microglia, the resident immune cells of the b...
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32320019104 | GPMDB
TranscriptomicsThe alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression
Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress
TranscriptomicsGene Array Analyzer (GAA): Alternative usage of gene arrays to study alternative splicing events (MoEx array)
The latest version of microarrays released by Affymetrix, the GeneChip Gene 1.0 ST Arrays (gene arrays), are designed in a similar fashion as exon arrays, which enables to identify differentially expressed exons, rather than only the expression level of whole transcripts. Here, we propose an extensi...
ORGANISM(S): Mus musculus 
2011-11-28 | E-GEOD-32998 | biostudies-arrayexpress
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