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UnknownProtein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance.
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S-EPMC3458358 | biostudies-literature
TranscriptomicsDetection of chromosomal aberrations in renal tumors by virtual karyotyping with SNP microarrays
Renal epithelial neoplasms have characteristic chromosomal imbalances that can be used for classification. We have previously shown that virtual karyotypes (v-karyotype) derived from SNP microarrays can be performed on formalin-fixed paraffin embedded (FFPE) tissue samples but a direct comparison wi...
ORGANISM(S): Homo sapiens 
2009-02-19 | E-GEOD-12808 | biostudies-arrayexpress
TranscriptomicsVirtual Karyotyping of Androgen Insensitive Prostate Cancer
We investigated chromosomal imbalances in samples from patients with androgen insensitive prostate cancer. 4 archival FFPE tumor samples were analyzed with Affymetrix 250K Nsp SNP microarrays and virtual-karyotype results for PTEN region were compared to PTEN deletion analysis by FISH.
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-13439 | biostudies-arrayexpress
TranscriptomicsVirtual-Karyotyping with SNP microarrays in morphologically challenging renal cell neoplasms
Genetic lesions characteristic for RCC subtypes can be identified by virtual karyotyping with SNP microarrays. In this study, we examined whether virtual karyotypes could be used to better classify a cohort of morphologically challenging/unclassified RCC. Tumor resection specimens from 17 patients w...
ORGANISM(S): Homo sapiens 
2009-03-13 | E-GEOD-14670 | biostudies-arrayexpress
TranscriptomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54348 | biostudies-arrayexpress
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
Transcriptomicswhole reference dataset (cell wall chip)
Data processing included: 1. Filtering of those bad quality image spots (these includes alterations on the shape or hybridization) 2. Filtering of low intensity which was done flagging with -50 those spots whose feature intensity was lower in any of both channels than the average of the local back...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-2105 | biostudies-arrayexpress
TranscriptomicsHog1 mutant 4 hours exposure to congo red (cell wall chip)
S. cerevisiae hog1 mutant strain was grown on YEPD. For Congo Red experiments, yest cells were grown overnight at 24 °C to an optical density 0.8 - 1 (A600). The culture was refreshed to 0.2 O.D and grown at 24 °C for 2h. Next, culture was divided into two parts. One continues growing under same c...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-2107 | biostudies-arrayexpress
ProteomicsSTIM1 Translocation to The Nucleus Protects Cells from DNA Damage
DNA damage represents a challenge for cells as this damage must be eliminated to preserve cell viability and the transmission of genetic information. To reduce or eliminate unscheduled chemical modifications in genomic DNA, an extensive signaling network, known as the DNA damage response (DDR) pathw...
ORGANISM(S): Homo sapiens (Human) 
2023-12-22 | PXD041181 | Pride
Dna repair  double strand breaks  fanconi anemia  nucleus  stim1 
TranscriptomicsDownregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype
Currently, multiple myeloma (MM) patients are broadly grouped into a non-hyperdiploid Group (nh-MM), highly enriched for IgH translocations, or into a hyperdiploid Group (h-MM), which is typically characterized by trisomies of some odd-numbered chromosomes. We compared the miRNA expression profiles...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-40308 | biostudies-arrayexpress
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