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TranscriptomicsDisparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages
Disparate Oxidant-related Gene Expression of Human Small Airway Epithelium Compared to Autologous Alveolar Macrophages in Response to the In Vivo Oxidant Stress of Cigarette Smoking The oxidant burden of cigarette smoking induces lung cell dysfunction, and play a significant role in the pathogenesis...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-13931 | biostudies-arrayexpress
ModelsLeander2021 - innate immune response to SARS-CoV-2 in the alveolar epithelium
A mathematical ODE based model of the innate immune response to SARS-CoV-2 in the alveolar epithelium.
2021-11-17 | MODEL2111170001 | BioModels
COVID-19 
TranscriptomicsPCR array of inflammatory cytokines and receptors in mouse lungs with NF-kappaB RelA mutant in alveolar epithelial cells during LPS stimulation
A murine model of RelA mutated throughout the alveolar epithelium was generated. Mice were anesthetized and intratracheally instilled with 50M-NM-
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-38398 | biostudies-arrayexpress
TranscriptomicsPCR array of inflammatory cytokines and receptors in mouse lungs with NF-kappaB RelA mutant in alveolar epithelial cells during pneumococcal pneumonia
A murine model of RelA mutated throughout the alveolar epithelium was generated. Mice were anesthetized and intratracheally instilled with 106 CFU of Streptococcus pneumoniae serotype 3 into the left lung lobe. Mice were euthanized after 15 hours after instillation, and left lung lobes were collecte...
ORGANISM(S): Mus musculus 
2012-08-03 | E-GEOD-38399 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of Alveolar epithelial cells
Freshly isolated type I and type II alveolar epithelial cells were investigated for transcriptomes with dual-color DNA microarray using 3DNA 50 kit.
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2160 | biostudies-arrayexpress
ProteomicsA Co-culture System Reveals a Cross-talk between Alveolar Epithelium and Pulmonary Microvascular Endothelium during SARS-CoV-2 Infection
SARS-CoV-2 seriously injures human alveoli and causes severe respiratory illness. Histopathologic evidences suggested alveolar-capillary barrier integrity is compromised in COVID-19 deaths, however, little is known about how it is disrupted. In this study, we investigated the effects of SARS-CoV-2 i...
ORGANISM(S): Homo sapiens (Human) 
2020-12-04 | PXD020470 | Pride
Hpaepic cells Sars-cov-2 Alveolar epithelium/endothelium co-culture system Hulec-5a cells 
TranscriptomicsKnockout mice reveal key roles for claudin-18 in alveolar fluid homeostasis.
Claudin proteins are major constituents of epithelial and endothelial tight junctions (TJ), where they serve as regulators of paracellular permeability to ions and solutes. Claudin-18, a member of the large claudin family, is highly expressed in lung epithelium. To elucidate the role of claudin-18 i...
ORGANISM(S): Mus musculus 
2014-04-06 | E-GEOD-48443 | biostudies-arrayexpress
ProteomicsComparative Tissue Proteomics for the Diagnosis of Indeterminate Pulmonary Nodules
We identified candidate protein biomarkers to distinguish lung adenocarcinomas from benign nodules. We employed shotgun proteomics using a multidimensional peptide separation approach coupled to tandem mass spectrometry (LC-MS/MS) to characterize proteomes of a collection of 34 benign lung nodules. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-09 | MSV000080236 | MassIVE
ProteomicsMetabolic reprogramming in the airway epithelium of high risk individuals
We investigated proteins identified by shotgun proteomics in cytologically normal airway epithelial cells from individuals at different levels of risk for lung cancer. We identified 2869 proteins in bronchial brushings from individuals at low, moderate or high risk for lung cancer. Pathway analysis ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000079331 | MassIVE
TranscriptomicsData expression in alveolar macrophages induced by lipopolysaccharide in humans
Rationale: Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary disease and asthma. Alveolar macrophages are the main resident leukocytes expos...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-40885 | biostudies-arrayexpress
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