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TranscriptomicsAcquisition of alveolar fate and differentiation competence by human fetal lung epithelial progenitor cells
Our data show that Wnt and FGF signalling, and the downstream transcription factors NKX2.1 and TFAP2C, promote human alveolar or airway fate respectively. Moreover, we have functionally validated cell-cell interactions in human lung alveolar patterning. We show that Wnt signalling from differentiati...
ORGANISM(S): Homo sapiens 
2022-02-28 | E-MTAB-11435 | biostudies-arrayexpress
GenomicsRUNX2 promotes pulmonary fibrosis through the conversion of alveolar fibroblasts into pathological fibroblasts
RUNX2 promotes pulmonary fibrosis through the conversion of alveolar fibroblasts into pathological fibroblasts
PRJNA1167229 | ENA
TranscriptomicsTranscription profiling of mouse secondary alveolar septae of neonatal lung tissue
The tips of secondary alveolar septae in day 6 neonatal mouse lung tissue were isolated using laser capture microscopy. RNA was isolated from pooled secondary alveolar tips and also from pooled neonatal day 6 whole lung tissue. The isolated RNAs were then amplified in parallel. Gene array profiling ...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-4220 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cancer-associated fibroblasts treated with dasatinib
Effect of Dasatinib on primary cancer-associated fibroblasts from lung cancer specimens.
ORGANISM(S): Homo sapiens 
2011-01-12 | E-MEXP-2546 | biostudies-arrayexpress
GenomicsDisease modeling of pulmonary fibrosis using human iPS cell-derived alveolar organoids (fibroblasts)
Disease modeling of pulmonary fibrosis using human iPS cell-derived alveolar organoids (fibroblasts)
PRJNA722176 | ENA
TranscriptomicsExpression data from (mouse) normal lung fibroblasts and carcinoma-associated fibroblasts
Cancer-associated fibroblasts (CAFs) have been reported to support tumor progression by a variety of mechanisms. However, their role in the progression of non-small cell lung cancer (NSCLC) remains poorly defined. In addition, the extent to which specific proteins secreted by CAFs contribute directl...
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48397 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat lung alveolar development
Lung alveolarization is a complex process that involves interactions between several cell types and leads to considerable increase in gas-exchange surface area. The step designated secondary septation includes elastogenesis from interstitial fibroblasts. We used microarrays to detail the global prog...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7491 | biostudies-arrayexpress
UnknownMaladaptive functional changes in alveolar fibroblasts due to perinatal hyperoxia impair epithelial differentiation.
Not available
S-EPMC8983125 | biostudies-literature
UnknownDirect reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells.
Not available
S-EPMC12185750 | biostudies-literature
ProteomicsTargeted immunotherapy rescues pulmonary fibrosis by reducing activated fibroblasts and regulating alveolar cell profile
Idiopathic pulmonary fibrosis (IPF) is a severe lung disease in the world, but has limited clinical therapies. Fibrosis maintains dynamic balance with overactivated fibroblasts. Given pulmonary cell regeneration, the lung may have self-repairing ability if fibrosis is removed by clearance of overact...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-19 | PXD053333 | Pride
Ipf Mouse Lnp Car-t Lung 
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