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MetabolomicsPreliminary exploration of the ability of HUC-MSCs to restore the lung microbiota and related metabolite disorders in IPF treatment: Combining 16S sequencing and metabolite analysis

Abstract

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive pulmonary disease, and effective therapies to reverse the natural course of IPF are lacking. A growing number of studies have shown that the use of human umbilical cord-derived mesenchymal stem cells (HUC-...

2025-09-01 | MTBLS12922 | MetaboLights
TranscriptomicsTranscriptome analysis reveals differential splicing events in IPF lung tissue
Objectives: Idiopathic pulmonary fibrosis (IPF) is a complex disease in which a multitude of proteins and networks are disrupted. Interrogation of genome-wide transcription through RNA sequencing (RNA-Seq) enables the determination of genes whose differential expression is most significant in IPF, a...
ORGANISM(S): Homo sapiens 
2014-03-27 | E-GEOD-52463 | biostudies-arrayexpress
MetabolomicsMetabolic analysis of Parp1 ko/wt Saline & Bleo Mouse Lung Fiboblasts and Human IPF & Normal Lung Fiboblasts (Part 3)
Not available
ORGANISM(S): Mus musculus 
ST000183 | MetabolomicsWorkbench
TranscriptomicsIdentification of the gene expression in IPF lung fibroblasts after demethylation
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease. Although the pathogenesis is poorly understood, evidence suggests that genetic and epigenetic alterations, such as DNA methylation, may play a key role. We used microarrays to see the gene expression in IPF fibroblasts after demethyl...
ORGANISM(S): Homo sapiens 
2016-02-16 | E-GEOD-69764 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics (Visium, 10x Genomics) data for human Idiopathic Pulmonary Fibrosis (IPF) and control lung tissue
Visium (10x Genomics) spatially resolved transcriptomics data generated from normal and Idiopathic Pulmonary Fibrosis (IPF) lung parenchyma tissues collected from human donors. The fresh-frozen tissues that were analyzed were from four healthy control (HC) subjects and from four IPF patients. For ea...
ORGANISM(S): Homo sapiens 
2024-05-28 | E-MTAB-14121 | biostudies-arrayexpress
UnknownThe European IPF registry (eurIPFreg): baseline characteristics and survival of patients with idiopathic pulmonary fibrosis.
Not available
S-EPMC6064050 | biostudies-literature
Transcriptomics40 IPF patients and 8 healthy controls
There is microscopic spatial and temporal heterogeneity of pathologic changes in idiopathic pulmonary fibrosis (IPF) lung tissue, which may relate to heterogeneity in pathophysiological mediators of disease and clinical progression. We measured gene expression in samples from lung biopsies or explan...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-53845 | biostudies-arrayexpress
TranscriptomicsGenomic Phenotype Of Non-Cultured IPF Fibroblasts
The activated fibroblast is the central effector cell for the progressive fibrotic process that characterizes idiopathic pulmonary fibrosis (IPF). An understanding of the genomic phenotype of this cell in isolation is essential to the understanding of disease pathogenesis and is integral to strategi...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-17978 | biostudies-arrayexpress
ProteomicsNovel integration of spatial and single-cell omics data sets enables deeper insights into IPF pathogenesis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by repetitive alveolar injuries with excessive deposition of extracellular matrix (ECM) proteins. A crucial need in understanding IPF pathogenesis is identifying cell types associated with histopathological regions, part...
ORGANISM(S): Homo sapiens (Human) 
2025-01-27 | PXD058805 | Pride
Human Idiopathic pulmonary fibrosis Lung Lcm-directed spatial proteomics Lc-ms/ms 
ProteomicsLabel free proteomics of the IPF Lung
Idiopathic pulmonary fibrosis is a debilitating disease leading ultimately to death without existing treatment. Here we profiled the proteome of 30 IPF cores and 10 control cores. The goal was to validate findings of snRNA-seq and new informatics means to mine the data (UNAGI) and evaluate in silico...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-16 | MSV000093129 | MassIVE
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